DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-A and Hex-C

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	243/447 - (54%)
Similarity:	323/447 - (72%)	Gaps:	8/447 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALDLG 159
            |.||.|..:|:|.||||:..|...|:.|||.:.|||:||||||.|||||||.|:|.||:||||||
  Fly     6 VRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDLG 70

  Fly   160 GTNFRVLLIHLQENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFT 224
            ||||||||:.|:.::|..::|:|||:|:.:|:|.|..||||||.||:.|:.:|::....||||||
  Fly    71 GTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGFT 135

  Fly   225 FSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCA 289
            ||||..||||.:|:|..|||||:||||..|||.::|.:||.||||..|.|.||||||||||||||
  Fly   136 FSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSCA 200

  Fly   290 WKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPR-KKHVLINTEWGAFGDNGALDFVRTEFDR 353
            .:|.:|::|:|||||.||||:|.||..:|..|:..: |:.|::|.||||||:.|.|||||||:||
  Fly   201 HRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYDR 265

  Fly   354 DIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQD------SEVLNTRGLFFTKY 412
            ::|..|:|..:|.||||.:|||:|.||||||::..:..::|....      |.:.....:|.|:|
  Fly   266 EVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRY 330

  Fly   413 VSEIEADEPGNFTNCRLVLEEL-GLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEP 476
            :||||.|....|.:.|.:::.| ||..|:..||..:|||||||:||||.||:.|::.|:|:....
  Fly   331 ISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTSNR 395

  Fly   477 TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533
            .|.||:||||||:||||...|.:.:.:|:|....:|:||||||||||||||||||.:
  Fly   396 RVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	119/194 (61%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	118/241 (49%)
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	118/193 (61%)
		PTZ00107	13..454	CDD:240270	239/440 (54%)
		Hexokinase_2	207..449	CDD:281689	118/241 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448964
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm6466
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	P	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
	13	12.750