DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and hkdc1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001108597.1	Gene:	hkdc1 / 321224	ZFINID:	ZDB-GENE-030131-9801	Length:	919	Species:	Danio rerio

Alignment Length:	466	Identity:	212/466 - (45%)
Similarity:	308/466 - (66%)	Gaps:	19/466 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SPQQIALLSA-----AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFV 138
            |.:..|:::|     |.:.|.:.:......||..|:||:..::..||.|||.|:|||.|:||...
Zfish   449 SAKGAAMVTAVAQRLASQRKEIDDTLAAFALTSTQLQEVKQKMHVELERGLKKETHPTASVKMLP 513

  Fly   139 TYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQE--NNDFQMESRIYAIPQHIMIGSGTQLFDHI 201
            |||...|:|.||||:|||||||||||||::.::.  .|..:|.::|||||..||.|:|.:|||||
Zfish   514 TYVYRTPDGTERGKYLALDLGGTNFRVLVVKIRTGMRNSVRMYNKIYAIPLEIMQGTGEELFDHI 578

  Fly   202 AECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIAR 266
            .:|:|:|:....:...|||||||||||..|.|:.||.|..|||||........|||.:|::||.|
Zfish   579 VQCISDFLDYMGMKNTRLPLGFTFSFPCNQTGIDKGDLVCWTKGFKATDCEGYDVVDMLREAIKR 643

  Fly   267 RGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLI 331
            |.:..:|:.||:|||.||:|:||:::..|:||||.|||:|.||||.::..|:...::.:   :.:
Zfish   644 RNEFDLDIVAIVNDTVGTMMTCAYEDPKCQIGLIAGTGSNVCYMEEMKNIEIVEGDEGQ---MCV 705

  Fly   332 NTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNG 396
            |||||.||:|..::.:||.:||::|..|:|.|||.||||.||||:||:||.:|:.:|:.|.||.|
Zfish   706 NTEWGGFGENDNIEDIRTRYDREVDSGSLNAGKQRFEKMTSGMYLGEIVRQILIDLTKRGFLFRG 770

  Fly   397 QDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHL 461
            :.:|.|.|:|:|.||::|:||:|... ....|.:|:.|||.:..| |...|:.:|..||:|||.|
Zfish   771 RITERLKTKGIFETKFLSQIESDRLA-LLQVRCILQSLGLDSTCD-DSIIVKEVCGAVSRRAAQL 833

  Fly   462 VSAGIATLINK------MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGS 520
            ..||:|.:::|      :|...:||||||::|:.||.|..::.|.:.:| .|....|.:||||||
Zfish   834 CGAGMAAIVDKIRENRGLDRLDITVGVDGTLYKLHPHFSTILKETVREL-APNCKVDFILSEDGS 897

  Fly   521 GRGAALVAAVA 531
            |:||||:.|||
Zfish   898 GKGAALITAVA 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	97/196 (49%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	105/239 (44%)
hkdc1	NP_001108597.1	Hexokinase_1	21..219	CDD:278764
		PTZ00107	29..460	CDD:240270	3/10 (30%)
		Hexokinase_2	225..459	CDD:281689	2/9 (22%)
		PTZ00107	462..908	CDD:240270	207/451 (46%)
		Hexokinase_1	469..667	CDD:278764	97/197 (49%)
		Hexokinase_2	673..907	CDD:281689	105/239 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2517
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm6466
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850