DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-A and HK3

DIOPT Version :10

Sequence 1:NP_524848.1 Gene:Hex-A / 45875 FlyBaseID:FBgn0001186 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_002106.2 Gene:HK3 / 3101 HGNCID:4925 Length:923 Species:Homo sapiens


Alignment Length:524 Identity:222/524 - (42%)
Similarity:319/524 - (60%) Gaps:38/524 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 AALSAT--------EKITTTTAAATKSATATTNATTATATTTNLTTHSPQ-QIALLSAAEKS--- 92
            |||:|.        |:.|...|.||.......:....:.....:...:|: .::|:.:.:..   
Human   401 AALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRG 465

  Fly    93 -KMVHELCQQLLLTDEQVQELC--YRILH--------ELRRGLAKDTHPKA-NVKCFVTYVQDLP 145
             .||..:..:|......::|..  :|:.|        ::|:.:||....:| :::...|:|:..|
Human   466 VAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATP 530

  Fly   146 NGNERGKFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMA 210
            :|:|||.|||||||||||||||:.:  ....|:.|.||:||:.:..|||.||||||.:|:.:|..
Human   531 DGSERGDFLALDLGGTNFRVLLVRV--TTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 593

  Fly   211 EHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVC 275
            :..:..:.||||||||||.|||||.:|:|..|||||..:....:|||.||::||.||..|:::|.
Human   594 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVV 658

  Fly   276 AILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGD 340
            ||:|||.||:|||.:::..|:||||||||.||||||.:........:..|   :.||.|||||||
Human   659 AIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGR---MCINMEWGAFGD 720

  Fly   341 NGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTR 405
            :|:|..:.|.||..:|..|||||||.|||||||||:||:||.:|:.:|..|:||.||..:.|.||
Human   721 DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTR 785

  Fly   406 GLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLI 470
            .:|.||::||||:|... ....|.:||:|||...:| |...|..:|:.||:|||.|..||:|.::
Human   786 DIFKTKFLSEIESDSLA-LRQVRAILEDLGLPLTSD-DALMVLEVCQAVSQRAAQLCGAGVAAVV 848

  Fly   471 NK------MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAA 529
            .|      ::|..|:|||||::|:.||:|.:|:...:.:| .|......:.||||||:|||||.|
Human   849 EKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVREL-APRCVVTFLQSEDGSGKGAALVTA 912

  Fly   530 VACR 533
            ||||
Human   913 VACR 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hex-ANP_524848.1 ASKHA_NBD_HK_meta 104..529 CDD:466869 203/441 (46%)
HK3NP_002106.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
ASKHA_NBD_HK3_meta_rpt1 41..471 CDD:466940 13/69 (19%)
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 84..220
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 221..460 11/58 (19%)
ASKHA_NBD_HK1-3_meta_rpt2 491..916 CDD:466941 205/432 (47%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 531..661 70/131 (53%)
Hexokinase large subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 662..901 112/244 (46%)
Blue background indicates that the domain is not in the aligned region.

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