DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and HK2

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_005264337.1	Gene:	HK2 / 3099	HGNCID:	4923	Length:	938	Species:	Homo sapiens

Alignment Length:	453	Identity:	227/453 - (50%)
Similarity:	309/453 - (68%)	Gaps:	16/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFL 154
            ::.:.|.:....:.|:||.:.|:..|...|:.:||...|||.|.||...|:|:..|:|.|.|:||
Human    17 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81

  Fly   155 ALDLGGTNFRVLLIHLQEN--NDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKE 217
            ||||||||||||.:.:.:|  ...:||::|||||:.||.||||||||||||||:|||.:..:..:
Human    82 ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDK 146

  Fly   218 RLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTT 282
            :||||||||||..|..|.:..|.:|||||..:||...|||.|::.||.||||..||:.|::|||.
Human   147 KLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTV 211

  Fly   283 GTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFV 347
            ||:|:|.:.:|||:||||||||:||||||.:...::...::.|   :.||.|||||||:|:|:.:
Human   212 GTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGR---MCINMEWGAFGDDGSLNDI 273

  Fly   348 RTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDS-EVLNTRGLFFTK 411
            |||||::||:.|:|||||.||||||||||||||||:||||.:..:||.|:.| |:||| |.|.||
Human   274 RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNT-GRFETK 337

  Fly   412 YVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEP 476
            .:|:||.::.| ....|.||..||| :.|..||.....||:.||.|:|.|.:|.:|.::.::.|.
Human   338 DISDIEGEKDG-IRKAREVLMRLGL-DPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKEN 400

  Fly   477 ------TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533
                  ..|:|||||||:.||.|...:.:.:.:|: ||.....:.||||||:|||:|.|||.|
Human   401 KGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV-PGCDVRFLRSEDGSGKGAAMVTAVAYR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	102/196 (52%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	118/240 (49%)
HK2	XP_005264337.1	PTZ00107	12..460	CDD:240270	224/449 (50%)
		Hexokinase_1	21..219	CDD:278764	102/197 (52%)
		Hexokinase_2	225..459	CDD:281689	118/240 (49%)
		PTZ00107	462..929	CDD:240270	1/1 (100%)
		Hexokinase_1	471..688	CDD:278764
		Hexokinase_2	694..928	CDD:281689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2536
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8559
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	LDO	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850