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Protein Alignment Hex-A and Hk3

DIOPT Version :10

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_071515.1	Gene:	Hk3 / 25060	RGDID:	2798	Length:	924	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	218/479 - (45%)
Similarity:	305/479 - (63%)	Gaps:	45/479 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TATTTNLTTH--------SPQQIALLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLA 125
            ||....|.||        :|.|::|              :||.....|::|       .:.|||.
  Rat   470 TAVAARLATHRRILEETLAPFQLSL--------------EQLTAVQAQMRE-------AMIRGLQ 513

  Fly   126 KDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIM 190
            .::   ::::...|||:..|:|:|||.|||||||||||||||:.:.|.: .|:.:::|:||:::.
  Rat   514 GES---SSLRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVRVAEGS-VQITNQVYSIPEYVA 574

  Fly   191 IGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNED 255
            .|||.:|||||.:|:.:|.....:..:.||||||||||.:||||.:|:|..||||||.:|...:|
  Rat   575 QGSGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQD 639

  Fly   256 VVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFA 320
            ||.||::||.||..|:::|.||:|||.||:|||.:.:..|::|||||||.||||||.:...   |
  Rat   640 VVYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPCCEMGLIVGTGTNACYMEELRNV---A 701

  Fly   321 AEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLV 385
            :......|:.||.|||||||:|:|..:.|.||..:|..|||||||.|||||||||:||:||.:|:
  Rat   702 SVPGDSGHMCINMEWGAFGDDGSLSMLGTCFDASVDQASINPGKQRFEKMISGMYLGEIVRHILL 766

  Fly   386 KMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYI 450
            .:|..|:||.||.::.|.||.:|.||::||||:|... ....|.:||:||||..:| |...|..:
  Rat   767 HLTSLGVLFRGQKTQCLQTRDIFKTKFLSEIESDSLA-LRQVRAILEDLGLTLTSD-DALMVLEV 829

  Fly   451 CECVSKRAAHLVSAGIATLINK------MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGI 509
            |:.||:|||.|..||:|.::.|      :.|.||:|||||::|:.||.|..|:...:.:| .|..
  Rat   830 CQAVSRRAAQLCGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSRLVSVTVRKL-APQC 893

  Fly   510 TFDLMLSEDGSGRGAALVAAVACR 533
            |...:.||||||:|||||..||||
  Rat   894 TVTFLQSEDGSGKGAALVTRVACR 917

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.