Protein Alignment Hex-A and Gck

DIOPT Version :9

• Sequence 1: NP_524848.1
• Gene: Hex-A / 45875
• FlyBaseID: FBgn0001186
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001257778.1
• Gene: Gck / 24385
• RGDID: 2670
• Length: 498
• Species: Rattus norvegicus
• Alignment Length: 400
• Identity: 193/400 - (48%)
• Similarity: 269/400 - (67%)
• Gaps: 17/400 - (4%)

  Fly   145 PNGNERGKFLALDLGGTNFRVLLIHLQENN----DFQMESRIYAIPQHIMIGSGTQLFDHIAECL 205
            |.| |.|.||:||||||||||:|:.:.|..    ..:.:.::|:||:..|.|:...|||:|:||:
  Rat   100 PRG-EVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 163

  Fly   206 SNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDV 270
            |:|:.:|.:..::||||||||||:|...|.||:|..|||||..:|....::|.||:|||.||||.
  Rat   164 SDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDF 228

  Fly   271 QIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEW 335
            ::||.|::|||..|::||.:::..|::|:|||||.||||||.::..||...::.|   :.:||||
  Rat   229 EMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR---MCVNTEW 290

  Fly   336 GAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSE 400
            |||||:|.||....|:||.:|..|.|||:|.:||:|.|.||||||||||:|:....:||:|:.||
  Rat   291 GAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASE 355

  Fly   401 VLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAG 465
            .|.|||.|.|::||::|:|. |:......:|..|||..:.. ||..||..||.||.||||:.|||
  Rat   356 QLRTRGAFETRFVSQVESDS-GDRKQIHNILSTLGLRPSVT-DCDIVRRACESVSTRAAHMCSAG 418

  Fly   466 IATLINKM------DEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGA 524
            :|.:||:|      |...:|||||||||:.||.|.......:.:| .|......:.||:||||||
  Rat   419 LAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPNCEITFIESEEGSGRGA 482

  Fly   525 ALVAAVACRE 534
            |||:||||::
  Rat   483 ALVSAVACKK 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	72/148 (49%)
		Hexokinase_2	296..530	CDD:397683	116/239 (49%)
Gck	NP_001257778.1	Hexokinase_1	<100..248	CDD:376323	72/148 (49%)
		Hexokinase_2	254..488	CDD:377112	116/239 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1815
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9035
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080