DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-A and Hkdc1

DIOPT Version :9

Sequence 1:NP_524848.1 Gene:Hex-A / 45875 FlyBaseID:FBgn0001186 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_663394.1 Gene:Hkdc1 / 216019 MGIID:2384910 Length:915 Species:Mus musculus


Alignment Length:479 Identity:213/479 - (44%)
Similarity:306/479 - (63%) Gaps:26/479 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 ATTNATTATATTTNLTTHSPQQIALLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLA 125
            :|..|...||..:.:..             :.|.:.::.....||.||:..:..::..||..||.
Mouse   449 STKGAAMVTAVASRVQA-------------QRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLK 500

  Fly   126 KDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIM 190
            |.||..|.||...|||..:|:|.|:|||||||||||||||||:.::..: .:|.::|:|||..||
Mouse   501 KKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRS-VRMYNKIFAIPLEIM 564

  Fly   191 IGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNED 255
            .|:|.:|||||.:|:::|:....:...:||||||||||.||..:.||.|..|||||.......||
Mouse   565 QGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATDCEGED 629

  Fly   256 VVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFA 320
            ||.:|::||.||.:..:|:.||:|||.||:|:|.:::..|:||||.|||:|.||||.:...||..
Mouse   630 VVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVD 694

  Fly   321 AEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLV 385
            .::.|   :.:|||||.|||||.:|.:||::|:::|..|:|.|||.:|||.||||:||:||.:|:
Mouse   695 GDEGR---MCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILI 756

  Fly   386 KMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYI 450
            .:|:.|:||.||.||.|.|||:|.||::|:||:|... ....|.:|::||| ::|..|...|:.:
Mouse   757 DLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLA-LLQVRRILQQLGL-DSTCEDSIVVKEV 819

  Fly   451 CECVSKRAAHLVSAGIATLINKMDEP------TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGI 509
            |..||:|||.:..||:|.::.|..|.      .|||||||::|:.||.|..::.|.:.:| .|..
Mouse   820 CGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKEL-APQC 883

  Fly   510 TFDLMLSEDGSGRGAALVAAVACR 533
            ....||||||||:||||:.|||.|
Mouse   884 DVTFMLSEDGSGKGAALITAVAKR 907

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-ANP_524848.1 Hexokinase_1 95..290 CDD:395278 92/194 (47%)
Hexokinase_2 296..530 CDD:397683 111/239 (46%)
Hkdc1NP_663394.1 Mitochondrial-binding peptide (MBP). /evidence=ECO:0000250|UniProtKB:Q2TB90 1..20
Hexokinase_1 21..219 CDD:376323
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 73..207
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 84..91
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 172..173
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 208..447
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 208..209
Hexokinase_2 225..459 CDD:377112 3/9 (33%)
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 291..294
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 413..415
Hexokinase_1 469..664 CDD:376323 92/195 (47%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 521..652 66/131 (50%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 532..536 3/3 (100%)