DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-A and hxk-1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001021106.1	Gene:	hxk-1 / 172751	WormBaseID:	WBGene00008780	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	241/473 - (50%)
Similarity:	320/473 - (67%)	Gaps:	15/473 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 ATTTNLTTHSPQQIALLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANV 134
            ||...:....|..:.|   :....::.|.||:|:|:|:|::.:...:...:.:|||..| .|..|
Worm    17 ATDAVIKKQRPPPLVL---SRPKDLIQEACQRLVLSDQQLRRIMQSMEKSMEQGLATST-KKVAV 77

  Fly   135 KCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIMIGSGTQLFD 199
            |...|||..:|||.|.|.||||||||||||||.|.|| ..:.:|..:|:.:|:.||.|:|..|||
Worm    78 KMLPTYVDSVPNGTESGDFLALDLGGTNFRVLHIKLQ-GKETKMTGKIFRVPESIMRGTGEALFD 141

  Fly   200 HIAECLSNFMAEHNVY-KERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDA 263
            |||.|::.||.|:::. .::||||||||||..|.|||||.|.||||||..:||...|||.||.:|
Worm   142 HIAGCMAKFMGENDLKDAQKLPLGFTFSFPCEQEGLTKGKLVTWTKGFKASGVEGVDVVTLLHEA 206

  Fly   264 IARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAA----EDP 324
            ..||.|:.|||.|:||||.||||:||::.::|:||:|||||.|||||||::.....|.    ...
Worm   207 CHRRKDIDIDVVALLNDTVGTLMACAFQENSCQIGVIVGTGTNACYMERLDRIPKLAGYVDEHGV 271

  Fly   325 RKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQ 389
            ..:.::||||||||||:|||||:|||:|..:|..|||||:..:|||||||||||..|:||..:.:
Worm   272 TPEEMIINTEWGAFGDDGALDFLRTEWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAK 336

  Fly   390 AGILFNGQDSEVLNTRGLFFTKYVSEIEA----DEPGNFTNCRLVLEELGLTNATDGDCANVRYI 450
            .|:||.| :|:.::....|.||:||||::    |:...|.....:||::|:...|..|||||.|:
Worm   337 QGLLFGG-NSDAISVPHCFPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYV 400

  Fly   451 CECVSKRAAHLVSAGIATLINKMDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLML 515
            |..:|.|||||.:||||.|:|:|::..||||||||||||||.:..|:..||.:||...|.:.|||
Worm   401 CSLISTRAAHLTAAGIAMLLNRMNKKHVTVGVDGSVYRFHPTYPTLLDAKIGELIVGDIEYKLML 465

  Fly   516 SEDGSGRGAALVAAVACR 533
            ||||||||||||||||.|
Worm   466 SEDGSGRGAALVAAVATR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	103/195 (53%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	128/241 (53%)
hxk-1	NP_001021106.1	COG5026	37..487	CDD:227359	237/450 (53%)
		Hexokinase_1	39..233	CDD:278764	103/195 (53%)
		Hexokinase_2	239..480	CDD:281689	128/241 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159241
Domainoid	1	1.000	248	1.000	Domainoid score	I1173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I900
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		otm14812
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	LDO	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890