DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and Hk1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_030100764.1	Gene:	Hk1 / 15275	MGIID:	96103	Length:	997	Species:	Mus musculus

Alignment Length:	453	Identity:	214/453 - (47%)
Similarity:	303/453 - (66%)	Gaps:	14/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKF 153
            ||:.:.:.|......|:.:.:.|:..::..|:..||.|:|:.:|.||...:||:.:|:|.|.|.|
Mouse   543 AEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDF 607

  Fly   154 LALDLGGTNFRVLLIHLQ--ENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYK 216
            ||||||||||||||:.::  :....:|.::||:||..||.|:|.:|||||..|:|:|:....:..
Mouse   608 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKG 672

  Fly   217 ERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDT 281
            .|:|||||||||.:|..|..|:|.||||||.....|..||..||:||:.||.:..:||.|::|||
Mouse   673 PRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDT 737

  Fly   282 TGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDF 346
            .||:|:||::..:|:||||||||:||||||.::..|:.   :..:..:.||.|||||||||.||.
Mouse   738 VGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMV---EGNQGQMCINMEWGAFGDNGCLDD 799

  Fly   347 VRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTK 411
            :||:||:.:|.:|:|.|||.|||||||||:||:||.:|:..|:.|.||.||.||.|.|||:|.||
Mouse   800 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETK 864

  Fly   412 YVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK---- 472
            ::|:||:|... ....|.:|::||| |:|..|...|:.:|..||||||.|..||:|.::.|
Mouse   865 FLSQIESDRLA-LLQVRAILQQLGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIREN 927

  Fly   473 --MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533
              :|...|||||||::|:.||.|..:|.:.:.:| .|..|...:|||||||:||||:.||..|
Mouse   928 RGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKEL-SPKCTVSFLLSEDGSGKGAALITAVGVR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	88/196 (45%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	119/239 (50%)
Hk1	XP_030100764.1	PTZ00107	75..539	CDD:240270
		Hexokinase_1	548..746	CDD:376323	88/197 (45%)
		Hexokinase_2	752..986	CDD:377112	119/239 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2461
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8788
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.850