Protein Alignment Hex-A and Gck

DIOPT Version :9

• Sequence 1: NP_524848.1
• Gene: Hex-A / 45875
• FlyBaseID: FBgn0001186
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_006514506.1
• Gene: Gck / 103988
• MGIID: 1270854
• Length: 487
• Species: Mus musculus
• Alignment Length: 414
• Identity: 190/414 - (45%)
• Similarity: 281/414 - (67%)
• Gaps: 15/414 - (3%)

  Fly    89 AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKF 153
            |:...:|.::..:..|.:|.::::..|:..|:.|||..:||.:|:||...|||:..|.|:|.|.|
Mouse    10 AQSLTLVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDF 74

  Fly   154 LALDLGGTNFRVLLIHLQENN----DFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNV 214
            |:||||||||||:|:.:.|..    ..:.:.::|:||:..|.|:...|||:|:||:|:|:.:|.:
Mouse    75 LSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQM 139

  Fly   215 YKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILN 279
            ..::||||||||||:|...:.||:|..|||||..:|....::|.||:|||.||||.::||.|::|
Mouse   140 KHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVN 204

  Fly   280 DTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGAL 344
            ||..|::||.:::..|::|:|||||.||||||.::..||...::.|   :.:||||||||::|.|
Mouse   205 DTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR---MCVNTEWGAFGNSGEL 266

  Fly   345 DFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFF 409
            |....|:||.:|..|:|||:|.:||:|.|.||||||||||:|:.:..:||:|:.||.|.|||.|.
Mouse   267 DEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFE 331

  Fly   410 TKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKM- 473
            |::||::|:|. |:......:|..|||..:. .||..||..||.||.||||:.|||:|.:||:|
Mouse   332 TRFVSQVESDS-GDRRQILNILSTLGLRPSV-ADCDIVRRACESVSTRAAHMCSAGLAGVINRMR 394

  Fly   474 -----DEPTVTVGVDGSVYRFHPK 492
                 |...:|||||||||:.||:
Mouse   395 ESRSEDVMRITVGVDGSVYKLHPR 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	87/198 (44%)
		Hexokinase_2	296..530	CDD:397683	101/203 (50%)
Gck	XP_006514506.1	COG5026	16..418	CDD:227359	188/406 (46%)
		Hexokinase_1	16..215	CDD:376323	87/198 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2461
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1846
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8788
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.920