DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and LOC100493823

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_002936904.3	Gene:	LOC100493823 / 100493823	-ID:	-	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	212/457 - (46%)
Similarity:	303/457 - (66%)	Gaps:	17/457 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNE 149
            |||   :.|.:.|:...|.|::|.:.::..|::.||:.||.|:||..|.||...|:|...|:|.|
Frog   462 LLS---QHKQIDEILALLQLSNENLFDIKERMMIELKNGLMKETHGSATVKMLPTFVYGTPDGTE 523

  Fly   150 RGKFLALDLGGTNFRVLLIHLQENND--FQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEH 212
            .|||||||||||||||||:.::....  .:|.::|:|||..||.|:|.:|||||.||::.|:...
Frog   524 WGKFLALDLGGTNFRVLLVKIRSGRRKYVRMYNKIFAIPLEIMQGTGEELFDHIVECIAEFLDYM 588

  Fly   213 NVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAI 277
            .:....||||||||||.:|..:.||.|..|||||.......:|||.:|::||.||.:..:|:.||
Frog   589 GIKGAPLPLGFTFSFPCKQERIDKGTLVGWTKGFKATDCEGQDVVDMLREAIKRRNEFDLDIVAI 653

  Fly   278 LNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNG 342
            :|||.||:|:|.:::.||:||||.|||:|.||||.::..|:...::.:   :.||||||.|||||
Frog   654 VNDTVGTMMTCGYEDPNCEIGLIAGTGSNVCYMEEMKNIEIVDGDEGK---MCINTEWGGFGDNG 715

  Fly   343 ALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGL 407
            .|..::|::|.|:|..|:|||||.:|||.||||:||:||.:|:.:|:.|:||.||.||.|.|:|:
Frog   716 CLADIQTKYDIDVDEKSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKCGLLFRGQISERLRTKGI 780

  Fly   408 FFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK 472
            |.||::|:||:|... ....|.:|::|||.:..| |...|:.:|..||.|||.|..||:|.:::|
Frog   781 FETKFLSQIESDRLA-LLQVRKILQQLGLDSTCD-DSIIVKEVCGAVSTRAAKLCGAGLAAVVDK 843

  Fly   473 MDEP------TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVA 531
            :.|.      .|||||||::|:.||.|..::.|.:.:| .|......||||||||:||||:.|||
Frog   844 IRENRDLEHLKVTVGVDGTLYKLHPHFSRILQETVKKL-SPQCDVTFMLSEDGSGKGAALITAVA 907

  Fly   532 CR 533
            .|
Frog   908 KR 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	91/196 (46%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	111/239 (46%)
LOC100493823	XP_002936904.3	Hexokinase_1	21..218	CDD:395278
		Hexokinase_2	224..458	CDD:397683
		Hexokinase_1	468..666	CDD:395278	91/197 (46%)
		Hexokinase_2	672..906	CDD:397683	111/239 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010