DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and hkdc1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_002935347.1	Gene:	hkdc1 / 100485269	XenbaseID:	XB-GENE-1002857	Length:	916	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	222/452 - (49%)
Similarity:	303/452 - (67%)	Gaps:	14/452 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFL 154
            ::.:.|.:....:.|:||.:.|:..|...::.:||.::|.|.|.||...|:|:..|:|.|.|.||
Frog    17 DQVQKVDKYLYHMRLSDETLLEVSSRFEKQMEKGLGQETSPTACVKMLPTFVRSTPDGTENGDFL 81

  Fly   155 ALDLGGTNFRVLLIHLQEN--NDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKE 217
            ||||||||||||.:.:.:|  ...:||::|||||..:|.|||.||||||||||.|||.:.|:..:
Frog    82 ALDLGGTNFRVLRVKVSDNGMKKVEMENQIYAIPADLMRGSGEQLFDHIAECLGNFMEKLNIKDK 146

  Fly   218 RLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTT 282
            :||||||||||.:|..|.:.:|..|||||...||..:|||.||:.||.:|||..||:.|::|||.
Frog   147 KLPLGFTFSFPCQQTKLDESILVNWTKGFKACGVEGKDVVTLLRKAIKKRGDFDIDIVAVVNDTV 211

  Fly   283 GTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFV 347
            ||:|:|.:.:|||:||||||||.||||||.:...:|...::.|   :.||.|||||||:|.||.:
Frog   212 GTMMTCGYDDHNCEIGLIVGTGTNACYMEDMRHIDLVEGDEGR---MCINMEWGAFGDDGCLDEI 273

  Fly   348 RTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKY 412
            ||:|||:||:.|:|||||.|||||||||||||||.:||||.:..:||.|:.:..|.|||.|.|:|
Frog   274 RTQFDREIDMGSLNPGKQLFEKMISGMYMGELVRFILVKMAKEDLLFEGRITADLLTRGHFETRY 338

  Fly   413 VSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEP- 476
            |||||.|:.| ......:|.:|||..:.:...|..| ||:.||.|:|:|.:|.:..::.::.|.
Frog   339 VSEIEKDKEG-IKKAHEILTKLGLEPSHEDSVATHR-ICQIVSTRSANLCAATLGAVLRRIRENK 401

  Fly   477 -----TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533
                 ..|||||||||:.||.|...:.:.:.:|: |......:.||||||:|||:|.|||.|
Frog   402 GVERLKSTVGVDGSVYKNHPHFARRLQKTVRRLV-PECDVRFIRSEDGSGKGAAMVTAVAYR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	99/196 (51%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	116/239 (49%)
hkdc1	XP_002935347.1	PTZ00107	12..460	CDD:240270	219/448 (49%)
		Hexokinase_1	471..666	CDD:376323
		Hexokinase_2	672..906	CDD:377112
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	1	1.100	-	-	LDO	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.140