Protein Alignment Hex-A and gck

DIOPT Version :9

• Sequence 1: NP_524848.1
• Gene: Hex-A / 45875
• FlyBaseID: FBgn0001186
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_012813876.1
• Gene: gck / 100124905
• XenbaseID: XB-GENE-981992
• Length: 465
• Species: Xenopus tropicalis
• Alignment Length: 470
• Identity: 221/470 - (47%)
• Similarity: 311/470 - (66%)
• Gaps: 31/470 - (6%)

  Fly    91 KSKM-------VHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGN 148
            |:||       |.::..:..|.:|.:..|..|:..|:.|||..:|:.:|:||...|||:..|:|:
 Frog     5 KNKMEATQIQKVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGS 69

  Fly   149 ERGKFLALDLGGTNFRVLLIHLQENNDFQ----MESRIYAIPQHIMIGSGTQLFDHIAECLSNFM 209
            |.|.|||||||||||||:|:.:.|:.:.|    .:.::|:||:..|.|:...|||:||||:|:::
 Frog    70 EVGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPEDAMTGTAEMLFDYIAECISDYL 134

  Fly   210 AEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDV 274
            .:.|:..::||||||||||:|...:.||:|..|||||..:|....:||.||:|||.||||.::||
 Frog   135 DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDV 199

  Fly   275 CAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFG 339
            .|::|||..|::||.:::|:|::|||||||.||||||.:...||...|:.|   :.:||||||||
 Frog   200 VAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGR---MCVNTEWGAFG 261

  Fly   340 DNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNT 404
            |.|.|:..|.|:||.:|..|:|||:|.:||||.|.||||||||||:||....::|.|:.||.|.|
 Frog   262 DTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENLIFGGESSEKLKT 326

  Fly   405 RGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATL 469
            ||.|.|::||:|||| ..:|.....:|..||: .||.|||..||..||.||.|||.:.|:|:|.:
 Frog   327 RGAFDTQFVSQIEAD-TSDFKQTLNILRTLGV-QATIGDCHAVRLACESVSTRAAVMCSSGLAAI 389

  Fly   470 INKMDE------PTVTVGVDGSVYRFHP----KFHNLMVEKISQLIKPGITFDLMLSEDGSGRGA 524
            :|:|.:      ..:|||||||||:.||    ||| ..|.|::.    |.....:.||:||||||
 Frog   390 LNRMHQSRRGELSRITVGVDGSVYKLHPSFKDKFH-ATVHKLTS----GCEITFIQSEEGSGRGA 449

  Fly   525 ALVAAVACREDILNG 539
            ||::|||.:..:|.|
 Frog   450 ALISAVAYKMAVLIG 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	90/198 (45%)
		Hexokinase_2	296..530	CDD:397683	121/243 (50%)
gck	XP_012813876.1	COG5026	6..458	CDD:227359	218/461 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060