DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and hk1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001096201.1	Gene:	hk1 / 100124752	XenbaseID:	XB-GENE-944850	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	453	Identity:	217/453 - (47%)
Similarity:	300/453 - (66%)	Gaps:	14/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKF 153
            :|:.:.:.|..::..|:.||:.|:..|:..|:..||.|.||..|.||...|||:..|:|.|.|.|
Frog   464 SEQRRQIDETLEEFKLSREQLLEVKRRMRIEIENGLRKKTHESAKVKMLPTYVRSTPDGTENGDF 528

  Fly   154 LALDLGGTNFRVLLIHLQ--ENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYK 216
            ||||||||||||||:.::  :....:|.::|||||..:|.|:|.:||||||.|:|:|:....:..
Frog   529 LALDLGGTNFRVLLVKIRSGKRRTVEMHNKIYAIPIDVMQGTGEELFDHIAHCISDFLDYMGIKG 593

  Fly   217 ERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDT 281
            .|||||||||||..|..|..|:|.||||||.......||||.||::.|.||.:..:||.||:|||
Frog   594 ARLPLGFTFSFPCMQTSLDAGILVTWTKGFKATDCEGEDVVNLLREGIKRREEFDLDVVAIVNDT 658

  Fly   282 TGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDF 346
            .||:|:||:::.||:||||||||:||||||..:..|:...:..|   :.:|.|||||||||.||.
Frog   659 VGTMMTCAYEDPNCEIGLIVGTGSNACYMEETKNIEMVDGDQGR---MCVNMEWGAFGDNGCLDD 720

  Fly   347 VRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTK 411
            :||.:|:.:|..|:|.|||.:||||||||:||:||.:|:..|:.|.||.||.||.|.|..:|.||
Frog   721 IRTVYDKAVDDLSLNSGKQRYEKMISGMYLGEIVRNILIDFTKRGFLFRGQISEALKTTSIFETK 785

  Fly   412 YVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK---- 472
            ::|:||:|... ....|.:|::||| |:|..|...|:.:|..||:|||.:..||:|.:::|
Frog   786 FLSQIESDRLA-LLQVRSILQQLGL-NSTCDDSIIVKEVCGAVSRRAAQVCGAGMAAVVDKIREN 848

  Fly   473 --MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533
              :|...|||||||::|:.||.|..:|.:.:..| .|......:|||||||:||||:.|||||
Frog   849 RGLDHLDVTVGVDGTLYKLHPHFSKIMHQTVKDL-APKCNVSFLLSEDGSGKGAALITAVACR 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	96/196 (49%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	112/239 (47%)
hk1	NP_001096201.1	PTZ00107	12..460	CDD:240270
		Hexokinase_1	469..667	CDD:376323	96/197 (49%)
		Hexokinase_2	673..907	CDD:377112	112/239 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110