Protein Alignment grau and ZFY

DIOPT Version :10

• Sequence 1: NP_788422.1
• Gene: grau / 45871
• FlyBaseID: FBgn0001133
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_003402.2
• Gene: ZFY / 7544
• HGNCID: 12870
• Length: 801
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 111/572 - (19%)
• Similarity: 207/572 - (36%)
• Gaps: 158/572 - (27%)

  Fly    84 KQDPEMVNTSWPEEV---LMPADVLAVDNDVGAQIN-VNPLDELDLSQPMSPEDSKVGIKTERQS 144
            :.||..|:::.||.:   :..||  ..::|:|..:: |....|.|....:..::|.:.:..|:
Human   233 EMDPCKVDSTCPEVIKVYIFKAD--PGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREK-- 293

  Fly   145 PDMELLFEDANNEQDED--------------------------------YEDDEDDDTDDLIVTR 177
                :::...|:.|.||                                :|...|:|.....|..
Human   294 ----MVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAAAAAVHEQQIDEDEMKTFVPI 354

  Fly   178 SGRKRKRDVAKPAKTKRGTVS----------VGRKGKEKMVVKRGPPKRIFKMERLPPFCKEDEE 232
            :......:.:...:.:.||.|          :||..|:|...||.|..|.::..
Human   355 AWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQTA----------- 408

  Fly   233 LIKRYIVMG----------CELC--IFLAEDFDGIREHFKDKHPD----ERPYIKCCGRKLNKRC 281
                 |::|          |.:|  .|.:..|  ::.|.|: ||:    ::.:...|....||:.
Human   409 -----IIIGPDGHPLTVYPCMICGKKFKSRGF--LKRHMKN-HPEHLAKKKYHCTDCDYTTNKKI 465

  Fly   282 LIQEHARRH----ENPEYIKCKDCGKVFANSSVLRAHWLVHHVPDEE-------CDFQ------- 328
            .:..|...|    :..:.|:|.:|||.|:::..|..|.:||......       |:::
Human   466 SLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLL 530

  Fly   329 ---------------CEDCGKRFSRRNLLELHKGSHVPVNERKFICPQCPKHNAFATEYHMQVHI 378
                           |.:|||.|  |:..||.|...:...|:.:.|..|...:|.::  :::.||
Human   531 NRHLLAVHSKNFPHICVECGKGF--RHPSELRKHMRIHTGEKPYQCQYCEYRSADSS--NLKTHI 591

  Fly   379 SMQHRKAANI-CHVCGKKIKDKAVFEKHVRLHFEESGPRI------------------------- 417
            ..:|.|.... |.:|.....|....::|..:|.|....:.
Human   592 KTKHSKEMPFKCDICLLTFSDTKEVQQHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDY 656

  Fly   418 --KCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSRALIGHKRYSHS-NVIYTCE 479
              ||..  ||........||:|:..|..: |:..|..|.....:...|..|....|: ::.:.|:
Human   657 PHKCEM--CEKGFHRPSELKKHVAVHKGK-KMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCK 718

  Fly   480 QCGKTFKKDISLKEHMAQHTGEPLYKCPFCPRTFNSNANMHSHKKKMHPVEW 531
            :|.|.|::...||:||..|:|..:|:|.:|..:....:....|...:|..::
Human   719 RCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDY 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..74	CDD:462262
		C2H2 Zn finger	272..290	CDD:275368	4/17 (24%)
		COG5048	<296..453	CDD:227381	44/213 (21%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		C2H2 Zn finger	359..409	CDD:275368	11/50 (22%)
		C2H2 Zn finger	360..378	CDD:275370	2/17 (12%)
		zf-C2H2_8	419..502	CDD:464935	23/83 (28%)
		C2H2 Zn finger	450..471	CDD:275368	4/20 (20%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		C2H2 Zn finger	506..524	CDD:275368	3/17 (18%)
ZFY	NP_003402.2	Zfx_Zfy_act	71..406	CDD:461400	33/180 (18%)
		COG5048	<417..592	CDD:227381	38/181 (21%)
		C2H2 Zn finger	423..443	CDD:275368	6/22 (27%)
		C2H2 Zn finger	454..478	CDD:275368	5/23 (22%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		COG5048	539..>676	CDD:227381	29/142 (20%)
		C2H2 Zn finger	546..566	CDD:275368	9/21 (43%)
		zf-H2C2_2	558..582	CDD:463886	6/23 (26%)
		C2H2 Zn finger	574..593	CDD:275368	5/20 (25%)
		C2H2 Zn finger	603..652	CDD:275368	6/48 (13%)
		C2H2 Zn finger	660..680	CDD:275368	6/21 (29%)
		zf-C2H2	715..737	CDD:395048	8/21 (38%)
		C2H2 Zn finger	717..737	CDD:275368	8/19 (42%)
		zf-H2C2_2	729..753	CDD:463886	9/23 (39%)
		C2H2 Zn finger	745..766	CDD:275368	3/20 (15%)
		C2H2 Zn finger	774..794	CDD:275368