DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grau and ZNF805

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	518	Identity:	121/518 - (23%)
Similarity:	194/518 - (37%)	Gaps:	116/518 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PADVLAVDNDVGAQINVNPLDELDLS-----QPMSPEDSKVGIKTERQSPDMELLFEDANNEQDE 160
            ||.|....:||..........:|||:     |.:..|:..:.:......|..||::...:.::..
Human     8 PAQVSVTFDDVAVTFTQEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPRPELIYHLEHGQEPW 72

  Fly   161 DYEDDEDDDTDDLIVTRSGRKRKRDVAKPAKTKR---------GTVSVGRKGKEKMVVKRGPPK- 215
            ..::|....      |..|.|.|....:|...:.         |.::.|..|..::    |.||
Human    73 TRKEDLSQG------TCPGDKGKPKSTEPTTCELALSEGISFWGQLTQGASGDSQL----GQPKD 127

  Fly   216 ----RIFKMERLPPFCKEDEE-----LIKRYIVMGC--ELC-------IFLAEDFDGIREHFKDK 262
                ...:.|||.|.....:|     :..::..:|.  .:|       :.|.:|......|...|
Human   128 QDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRIIQDRVSLGDDVHDCDSHGSGK 192

  Fly   263 HP---DERPYIKC--CGRKLNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLRAHWLVH---- 318
            :|   :|....||  |.:..||:.|:..|.|.|...:..:|.:|||.|:.|:.|..|.:||
Human   193 NPVIQEEENIFKCNECEKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEK 257

  Fly   319 ---------------------HVPDEECDFQCEDCGKRFSRRNLLELHKGSHVPVNERKFICPQC 362
                                 .:...|..::|.:|||.|:.|:...||..||  ..|:.|:|.:|
Human   258 PYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSH--TGEKPFVCKEC 320

  Fly   363 P-------------------------------KHNAFATEYHMQVHISMQHRKAANICHVCGKKI 396
            .                               ||.::.. :|.|.|...:..:    |..|||..
Human   321 GKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLM-WHQQTHTGEKPYE----CSECGKAF 380

  Fly   397 KDKAVFEKHVRLHFEESGPRIKCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSR 461
            .:.|....|..:|..|.  ..:|  .:|.........||:|.|.|..| |.::||||||:..:..
Human   381 CESAALIHHYVIHTGEK--PFEC--LECGKAFNHRSYLKRHQRIHTGE-KPYVCSECGKAFTHCS 440

  Fly   462 ALIGHKRYSHSNVIYTCEQCGKTFKKDISLKEHMAQHTGEPLYKCPFCPRTFNSNANMHSHKK 524
            ..|.|||.......:.|::|||.|.....|..|.:.||||..|:|..|.:.||..:.:..|::
Human   441 TFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRHQR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071
		C2H2 Zn finger	272..290	CDD:275368	7/19 (37%)
		COG5048	<296..453	CDD:227381	49/212 (23%)
		C2H2 Zn finger	298..318	CDD:275368	8/19 (42%)
		SIR2	<316..>415	CDD:294129	30/154 (19%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		C2H2 Zn finger	359..409	CDD:275368	13/80 (16%)
		C2H2 Zn finger	360..378	CDD:275370	5/48 (10%)
		zf-C2H2_8	419..495	CDD:292531	25/75 (33%)
		C2H2 Zn finger	450..471	CDD:275368	10/20 (50%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	506..524	CDD:275368	5/17 (29%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630	10/59 (17%)
		KRAB	13..52	CDD:279668	7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162		10/52 (19%)
		COG5048	192..568	CDD:227381	86/324 (27%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-H2C2_2	218..241	CDD:290200	7/22 (32%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		zf-H2C2_2	245..270	CDD:290200	4/24 (17%)
		C2H2 Zn finger	261..281	CDD:275368	0/19 (0%)
		zf-H2C2_2	273..298	CDD:290200	6/24 (25%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		zf-H2C2_2	305..324	CDD:290200	7/20 (35%)
		C2H2 Zn finger	317..337	CDD:275368	2/19 (11%)
		zf-C2H2	343..365	CDD:278523	4/22 (18%)
		C2H2 Zn finger	345..365	CDD:275368	4/20 (20%)
		zf-H2C2_2	357..380	CDD:290200	7/27 (26%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		zf-C2H2	399..421	CDD:278523	6/23 (26%)
		C2H2 Zn finger	401..421	CDD:275368	6/21 (29%)
		zf-H2C2_2	413..438	CDD:290200	13/25 (52%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		zf-H2C2_2	445..466	CDD:290200	8/20 (40%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		zf-H2C2_2	469..494	CDD:290200	10/24 (42%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	498..520	CDD:290200	1/6 (17%)
		C2H2 Zn finger	513..533	CDD:275368
		zf-H2C2_2	525..550	CDD:290200
		C2H2 Zn finger	541..561	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000