DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grau and ZK686.5

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001023030.2	Gene:	ZK686.5 / 3565160	WormBaseID:	WBGene00022795	Length:	263	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	63/310 - (20%)
Similarity:	112/310 - (36%)	Gaps:	85/310 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VAEVLRQHFWFEVLPNDEISKVICNVCWTQVSE------FHQFYVSIQEAQVIYATTSKFKQDPE 88
            |.::.:.|.:.|.|.|.|..|....:|.....|      |.:|.|               ::.||
Worm     9 VDDIKKLHIYNEYLLNRETLKATKELCELMSHESVGCSCFQEFPV---------------EKAPE 58

  Fly    89 MVNTSWPEEVLMPADVLAVDNDVGAQINVNPLDELDLSQPMSPEDSKVGIKTERQSPDMELLFED 153
            |     |:..::..|.....::..|...:........|.|.:  .|.:..| :|::.|      :
Worm    59 M-----PDFTIIQPDRKFDGDNAAAVAGIFVRSSTSSSFPSA--SSYIAAK-KRKNVD------N 109

  Fly   154 ANNEQDEDYEDDEDDDTDDLIVTRSGRKRKRDVAKPAKTKRGTVSVG------RKGKEKMVVKRG 212
            .:..:...|:|.:..:|:::          |::.|......|.|...      ::.:|| .:||
Worm   110 TSTRKPYSYKDRKRKNTEEI----------RNIKKKLFMDLGIVRTNCGIDNEKQDREK-AMKR- 162

  Fly   213 PPKRIFKMERLPPFCKEDEELIKRYIVMGCELCIFLAEDFDGIRE---HFKDKHPDERPYIKC-- 272
                           |..|.::..|    ||||   .::|...:.   |....|  ..|||:|
Worm   163 ---------------KVTETIVTTY----CELC---EQNFSSSKMLLLHRGKVH--NTPYIECHL 203

  Fly   273 CGRKLNKRCLIQEHARRHENPE---YIKCKDCGKVFANSSVLRAHWLVHH 319
            |.:..::......|.:.|..|.   |::|:.|.:.|.:...||.||.|.|
Worm   204 CMKLFSQTIQFNRHMKTHYGPNAKIYVQCELCDRQFKDKQSLRTHWDVSH 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071	12/52 (23%)
		C2H2 Zn finger	272..290	CDD:275368	3/19 (16%)
		COG5048	<296..453	CDD:227381	9/24 (38%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		SIR2	<316..>415	CDD:294129	2/4 (50%)
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	359..409	CDD:275368
		C2H2 Zn finger	360..378	CDD:275370
		zf-C2H2_8	419..495	CDD:292531
		C2H2 Zn finger	450..471	CDD:275368
		C2H2 Zn finger	478..498	CDD:275368
		C2H2 Zn finger	506..524	CDD:275368
ZK686.5	NP_001023030.2	C2H2 Zn finger	173..194	CDD:275368	6/23 (26%)
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		zf-C2H2_8	<204..251	CDD:292531	12/46 (26%)
		C2H2 Zn finger	232..248	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930