DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grau and fezf-1

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_502594.2	Gene:	fezf-1 / 3564888	WormBaseID:	WBGene00012639	Length:	218	Species:	Caenorhabditis elegans

Alignment Length:	232	Identity:	62/232 - (26%)
Similarity:	98/232 - (42%)	Gaps:	44/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 EKMVVKRGPPKRIFKMERLPPF-------------CKEDEELIKRYIVMGCELCIFLAEDFDGIR 256
            |.::.....||.:.:...:.||             ..:||...|::   .||:|   .:.|:.
Worm     7 EVLLADSPSPKSLCRSSGIFPFPLPSSNSIFAESSSGDDENSRKKF---PCEIC---GKQFNA-- 63

  Fly   257 EHFK-----DKHPDERPYI-KCCGRKLNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLRAHW 315
             |:.     ..|..|||:: |.||:...:...:..|...|.:.:..|||.|||.|..||.|..|.
Worm    64 -HYNLTRHMPVHTGERPFVCKVCGKAFRQASTLCRHKIIHTDSKPHKCKTCGKCFNRSSTLNTHV 127

  Fly   316 LVHH--VPDEECDFQCEDCGKRFSRRNLLELHKGSHVPVNERKFICPQCPK--HNAFATEYHMQV 376
            .:|.  .|     |.||.|||.|.:....:.|:.:|  .:.:||.|..|.:  |.::...:||..
Worm   128 RIHQGFKP-----FVCEICGKGFHQNGNYKNHRLTH--EDTKKFSCSICSRAFHQSYNLAFHMFT 185

  Fly   377 HISMQHRKAANICHVCGKKIKDKAVFEKHVR-LHFEE 412
            |  .:|:...  ||||.|........:||:| :|..:
Worm   186 H--EEHKPFT--CHVCSKGFCRNFDLKKHLRKMHMTQ 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071
		C2H2 Zn finger	272..290	CDD:275368	3/17 (18%)
		COG5048	<296..453	CDD:227381	40/122 (33%)
		C2H2 Zn finger	298..318	CDD:275368	10/19 (53%)
		SIR2	<316..>415	CDD:294129	29/102 (28%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..409	CDD:275368	15/52 (29%)
		C2H2 Zn finger	360..378	CDD:275370	4/19 (21%)
		zf-C2H2_8	419..495	CDD:292531
		C2H2 Zn finger	450..471	CDD:275368
		C2H2 Zn finger	478..498	CDD:275368
		C2H2 Zn finger	506..524	CDD:275368
fezf-1	NP_502594.2	COG5048	<13..212	CDD:227381	59/218 (27%)
		DUF3449	<50..>70	CDD:288759	6/28 (21%)
		C2H2 Zn finger	54..74	CDD:275368	5/25 (20%)
		zf-H2C2_2	66..91	CDD:290200	7/24 (29%)
		C2H2 Zn finger	82..102	CDD:275368	4/19 (21%)
		C2H2 Zn finger	110..130	CDD:275368	10/19 (53%)
		C2H2 Zn finger	138..158	CDD:275368	7/19 (37%)
		C2H2 Zn finger	166..186	CDD:275368	5/19 (26%)
		C2H2 Zn finger	194..212	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000