DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grau and CG11696

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	634	Identity:	186/634 - (29%)
Similarity:	280/634 - (44%)	Gaps:	110/634 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ICRLCLRGVSGAQMCLQIFDVD-----SGESKVAEVLRQHFWFEVLPNDEISKVICNVCWTQVSE 62
            ||||||   ..|:..:.||..:     ....::||::.:|....:..||.:|..:||.||.|::|
  Fly     2 ICRLCL---EDAEHGVPIFGQEPPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQLAE 63

  Fly    63 FHQFYVSIQEAQVIYATTSKFKQD-PEMVNTSWPEEVLM-------------------------- 100
            ..||...:.|.|.....:.:.|.: ||:...:.||..|:
  Fly    64 IEQFCSMVAEKQRSLHRSLQLKTELPELPELTEPEPALVVWNTESPIEPKLSYEGDDIKDHILCE 128

  Fly   101 PA-DVLAV----DNDVG--AQINVNPLDELDLSQ-----PMSP---------------------- 131
            |. |.|:.    |:|.|  .:.:..|..:.|..:     |:.|
  Fly   129 PVIDALSAGDEKDSDYGDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKRKY 193

  Fly   132 ----EDSKVGIK----TERQSPDMELLFEDANNEQDEDYEDDEDDDTD---DLIVTRSGRKRKRD 185
                :.:|..|.    .|.::...||....|..|.|:|.::||:|:.|   :|......:.:.|.
  Fly   194 EKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQPKPRG 258

  Fly   186 VAKPAKTKRGTVSVGRKGKEKMVVKRGPPKRIFKMERLPPFCKEDEELIKRYIVMGCELCIFLAE 250
            .....|||:...:.......::.|||..             .||.::.|...:.:.|.:|....|
  Fly   259 KRGRPKTKKLVTADDNDDTSEVPVKRSS-------------IKEMDDYIAANVKLDCAICAAPLE 310

  Fly   251 DFDGIREHFKDKHPDERPYIKCCGRKLNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLRAHW 315
            ||:.::.||:.:| |...|:|||..:..||.|..:|...|::|:|..|:.|.|.|.|.:....|.
  Fly   311 DFNDLKRHFRVEH-DCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHM 374

  Fly   316 LVHHVPDEECDFQCEDCGKRFSRRNLLELHKGSHVPVNERKFICPQCPKHNAFATEYHMQVHISM 380
            |..|...:|...||..|..||:::.||.:|...| ...||..:|..|.|  .|.|::.:..|:..
  Fly   375 LRFHSQQQELVHQCAICEARFAKKFLLTMHLKGH-KGTERPEVCDTCSK--TFRTKFELSAHVKR 436

  Fly   381 QHRKAAN----ICHVCGKKIKDKAVFEKHVR-LHFEESGPRIKCPRPDCESWLKDEDNLKQHLRR 440
            .|  ||:    ||.:||...:.||.|..|.: ||.:.....::|..  |..||:||.:|::||.|
  Fly   437 MH--AADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTL--CGRWLRDERSLRKHLAR 497

  Fly   441 HND-EGKL-FICSECGKSCKNSRALIGHKRYSHSNVIYTCEQCGKTFKKDISLKEHMAQHTGEPL 503
            |:| :|.. :.|..|.....:..||..|.||.||...:.|..|.|.||...:|.||||.|||..|
  Fly   498 HDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDL 562

  Fly   504 YKCPFCPRTFNSNANMHSHKKKMHPVEWDIWRKTKTGSSQKVLPSAQVA 552
            |:|.||.|||.|:||||:|||||||.:|  .||....||.....:|.:|
  Fly   563 YQCQFCTRTFKSHANMHNHKKKMHPNDW--VRKYSQPSSSITSTAAPLA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071	25/78 (32%)
		C2H2 Zn finger	272..290	CDD:275368	6/17 (35%)
		COG5048	<296..453	CDD:227381	53/163 (33%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		SIR2	<316..>415	CDD:294129	33/103 (32%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..409	CDD:275368	17/54 (31%)
		C2H2 Zn finger	360..378	CDD:275370	4/17 (24%)
		zf-C2H2_8	419..495	CDD:292531	29/77 (38%)
		C2H2 Zn finger	450..471	CDD:275368	7/20 (35%)
		C2H2 Zn finger	478..498	CDD:275368	10/19 (53%)
		C2H2 Zn finger	506..524	CDD:275368	12/17 (71%)
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	25/78 (32%)
		C2H2 Zn finger	332..349	CDD:275368	5/16 (31%)
		C2H2 Zn finger	357..378	CDD:275368	7/20 (35%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..438	CDD:275368	6/22 (27%)
		C2H2 Zn finger	447..465	CDD:275368	7/17 (41%)
		C2H2 Zn finger	478..498	CDD:275368	9/21 (43%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..583	CDD:275368	12/17 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910