DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grau and CG2889

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	168/588 - (28%)
Similarity:	273/588 - (46%)	Gaps:	85/588 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ICRLCLRGVS-GAQMCLQIFDVDS--GESKVAEVLRQHFWFEVLPNDEISKVICNVCWTQVSEFH 64
            |||||||.:| |:.:.|  |:.|.  .|:::.:::.:....|:||:|.||..:|..|...:.:|:
  Fly     2 ICRLCLRCLSPGSAVFL--FETDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDFN 64

  Fly    65 QFYVSIQEAQVIYATTSKF-KQDPEMVNTSWPEEVLMPADV-----LAVDND-----------VG 112
            .|:..:::.|.  :...:| ..|.:.....|...|.:..::     .|.|.|           :|
  Fly    65 GFWQLVEQKQC--SLKKEFLTVDVDCAAMKWTGGVDVDVNIDELPLAAGDMDEKPLDLHNLSLLG 127

  Fly   113 AQINVNPLDELDLSQPM-------SPEDSKVGIKTERQSPDMELLFEDANNEQDEDYEDDEDDDT 170
            :.::|| :|.:::.:|:       ..||.|..::.....|::        .|...:.|.|..||
  Fly   128 SVLDVN-VDSVEVREPIKEQLPCEEEEDEKPCLQASDSEPEV--------TEGQPESESDSSDD- 182

  Fly   171 DDLIVTRSGRKRKRDVAKPAKTKRGTVSVGRK--------GKEKMVVKRGPPKRIFK-------- 219
            :.|:..:|..|.||..:..:...:|.:|:.::        ||.:.  ::.|.:|...
  Fly   183 EPLVRLKSKMKPKRKTSARSSKDQGPISLQQELADLLDDGGKRRR--RKAPDQRTTTESQESELQ 245

  Fly   220 --MERLPPFC------KEDEELIKRYIVMGCELCIFLAEDFDGIREHFKDKHPDERPYIKCCGRK 276
              :||.|..|      |..|:.|..|:...|:||.|.|.....::.||.:.|..|. ||||||:.
  Fly   246 AVLERKPKGCSRAQLAKSYEKAIASYMSASCDLCEFSAPYLSELKTHFLEVHQREY-YIKCCGKV 309

  Fly   277 LNKRCLIQEHARRHENPEYIKCKDCGKVFANSSVLRAH-WLVHHVP---DEECDFQCEDCGKRFS 337
            ..:...:.:|.|:|.||:...|..|.|...:...|..| ..||:..   .:...|.|..|.:.||
  Fly   310 FTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHIETVHNKVAQIGKVLKFPCPKCERTFS 374

  Fly   338 RRNLLELHKGSHVPVNERKFICPQCPKHNAFATEYHMQVHISMQHRKA-ANICHVCGKKIKDKAV 401
            ....:..|...| ..::.:..|..|.|  :||..:.::.||...|... .::|.:||||.|.|..
  Fly   375 SERRMANHLAKH-DTDQLEHTCEICCK--SFANVHRLRRHIQSIHEDLHRHVCDICGKKFKFKPS 436

  Fly   402 FEKHVRLHFEESGPRIKCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSRALIGH 466
            ||:|:..|.....|.::|  |.|..|||:|.:|:.|...|:....  :|..|||:|.:..||.||
  Fly   437 FERHLLEHQGVVAPAVEC--PICRVWLKNEHSLRLHRFTHDSTDT--VCPHCGKTCTSRTALRGH 497

  Fly   467 KRYSH---SNVIYTCEQCGKTFKKDISLKEHMAQHTGEPLYKCPFCPRTFNSNANMHSHKKKMHP 528
            .:|:|   :|:  .|..|.||||:..:|.||||.|||..||.||.||:...|.:||:.|.|:.|.
  Fly   498 VKYAHKLTTNL--QCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHA 560

  Fly   529 VEW 531
            .||
  Fly   561 DEW 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071	24/76 (32%)
		C2H2 Zn finger	272..290	CDD:275368	5/17 (29%)
		COG5048	<296..453	CDD:227381	45/161 (28%)
		C2H2 Zn finger	298..318	CDD:275368	5/20 (25%)
		SIR2	<316..>415	CDD:294129	28/102 (27%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		C2H2 Zn finger	359..409	CDD:275368	18/50 (36%)
		C2H2 Zn finger	360..378	CDD:275370	4/17 (24%)
		zf-C2H2_8	419..495	CDD:292531	30/78 (38%)
		C2H2 Zn finger	450..471	CDD:275368	10/20 (50%)
		C2H2 Zn finger	478..498	CDD:275368	11/19 (58%)
		C2H2 Zn finger	506..524	CDD:275368	8/17 (47%)
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	24/80 (30%)
		C2H2 Zn finger	276..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	306..323	CDD:275368	4/16 (25%)
		C2H2 Zn finger	331..352	CDD:275368	5/20 (25%)
		C2H2 Zn finger	366..386	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	7/22 (32%)
		C2H2 Zn finger	424..444	CDD:275368	10/19 (53%)
		C2H2 Zn finger	481..502	CDD:275368	10/20 (50%)
		C2H2 Zn finger	510..530	CDD:275368	11/19 (58%)
		C2H2 Zn finger	538..556	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25790
OrthoDB	1	1.010	-	-		D28261at33392
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23225
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.960