DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grau and PRDM5

DIOPT Version :9

Sequence 1:	NP_788422.1	Gene:	grau / 45871	FlyBaseID:	FBgn0001133	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001366033.1	Gene:	PRDM5 / 11107	HGNCID:	9349	Length:	641	Species:	Homo sapiens

Alignment Length:	572	Identity:	135/572 - (23%)
Similarity:	214/572 - (37%)	Gaps:	142/572 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SIQEAQ-VIYATTSKFKQDPEMVNTSWPEEVLMPADVLAVDNDVGAQ------INVNPLDELDLS 126
            :|||.: :.|......:.|.|::             :..:|:|:.|:      :.|....|::.|
Human    98 AIQEGENIFYLAVEDIETDTELL-------------IGYLDSDMEAEEEEQQIMTVIKEGEVENS 149

  Fly   127 QPMSPEDSK--VGIKTERQSPDMELLF--ED--ANNEQDEDYEDDEDDD---------------- 169
            :..|....|  :|.|.:...|..|..|  ||  |.:.|....:..|:.:
Human   150 RRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQAL 214

  Fly   170 -------TDDLIVTRSGRKRKRDVAKPA-----------KTKRGTV-------SVGRKGKEKMVV 209
                   |....:..|.|..:..|...:           :|.||..       |.|::.|.|..:
Human   215 QRHVLQCTAKSSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDARFVCKADSCGKRLKSKDAL 279

  Fly   210 KR-------GPPKR-------------------------IFK-MERLPPFCKEDEELIKRYIV-- 239
            ||       |.||:                         ||. .|.:..|...::  :||:::
Human   280 KRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQ--LKRHMITH 342

  Fly   240 ----------------MGCELCIFLAEDFDGIREHFKDKHPDERPYIKC--CGRKLNKRCLIQEH 286
                            ..||:|....:..|.:..| |..|.:::|| ||  ||:....|.:.:.|
Human   343 SDMRLSPLIFLIEKRPYNCEICNKSFKRLDQVGAH-KVIHSEDKPY-KCKLCGKGFAHRNVYKNH 405

  Fly   287 ARRHENPEYIKCKDCGKVFANSSVLRAHWLVHHVPDEECDFQCEDCGKRFSRRNLLELHKGSHVP 351
            .:.|......:|::|..:|.....|:.|.|:|   :.|..|:|..|...|.|::.|.:|.   ..
Human   406 KKTHSEERPFQCEECKALFRTPFSLQRHLLIH---NSERTFKCHHCDATFKRKDTLNVHV---QV 464

  Fly   352 VNER--KFICPQCPKHNAFATEYHMQVHISMQHRKAANICHVCGKKIKDKAVFEKHVRLHFEESG 414
            |:||  |:.|..|.|  ||.|...::.|......:...||..||:|.........|:|.|   :|
Human   465 VHERHKKYRCELCNK--AFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSH---TG 524

  Fly   415 PR-IKCPRPDCESWLKDEDNLKQHLRRHNDEGKLFICSECGKSCKNSRALIGHKRYSHSNVIYTC 478
            .| .:||.  ||......|.||.|:|.|..| |.:.||||.|:....|.|..|||.......:.|
Human   525 ERPYQCPY--CEKGFSKNDGLKMHIRTHTRE-KPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQC 586

  Fly   479 EQCGKTFK-KDISLKEHMAQHTGEPLYKCPFCPRTFNSNANMHSHKKKMHPV 529
            :.|...|. |.:.::..|..:...||.:|.||.:.|..|..:..|...:|.|
Human   587 DVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGV 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grau	NP_788422.1	zf-AD	3..77	CDD:285071	3/8 (38%)
		C2H2 Zn finger	272..290	CDD:275368	5/19 (26%)
		COG5048	<296..453	CDD:227381	50/159 (31%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		SIR2	<316..>415	CDD:294129	29/100 (29%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		C2H2 Zn finger	359..409	CDD:275368	14/49 (29%)
		C2H2 Zn finger	360..378	CDD:275370	5/17 (29%)
		zf-C2H2_8	419..495	CDD:292531	26/76 (34%)
		C2H2 Zn finger	450..471	CDD:275368	10/20 (50%)
		C2H2 Zn finger	478..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	506..524	CDD:275368	6/17 (35%)
PRDM5	NP_001366033.1	PR-SET_PRDM5	2..128	CDD:380967	7/42 (17%)
		COG5048	<145..338	CDD:227381	35/194 (18%)
		C2H2 Zn finger	169..190	CDD:275368	7/20 (35%)
		C2H2 Zn finger	201..221	CDD:275368	0/19 (0%)
		C2H2 Zn finger	236..256	CDD:275368	1/19 (5%)
		COG5048	262..631	CDD:227381	101/386 (26%)
		C2H2 Zn finger	264..287	CDD:275368	6/22 (27%)
		C2H2 Zn finger	297..317	CDD:275368	0/19 (0%)
		C2H2 Zn finger	322..342	CDD:275368	4/21 (19%)
		C2H2 Zn finger	361..381	CDD:275368	6/20 (30%)
		C2H2 Zn finger	389..409	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		C2H2 Zn finger	445..462	CDD:275368	5/16 (31%)
		C2H2 Zn finger	474..494	CDD:275368	7/21 (33%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		C2H2 Zn finger	530..550	CDD:275368	9/21 (43%)
		C2H2 Zn finger	558..578	CDD:275368	10/19 (53%)
		C2H2 Zn finger	586..606	CDD:275368	5/19 (26%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910