DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUC4 and mesh

DIOPT Version :9

Sequence 1:	NP_001309397.1	Gene:	MUC4 / 4585	HGNCID:	7514	Length:	7418	Species:	Homo sapiens
Sequence 2:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster

Alignment Length:	1176	Identity:	241/1176 - (20%)
Similarity:	359/1176 - (30%)	Gaps:	477/1176 - (40%)

- Green bases have known domain annotations that are detailed below.

Human  6163 HATPLPVTSTSSASTGHATPLPVTDASSVSTGHATPLPVTDTSSASTGDTTPLPVTDTSSASTGQ 6227
            :|.|.||..|.          |...|..|....|||.|  ..:.|....|.||.:.        :
  Fly    36 NAVPEPVKVTK----------PKAQAEFVEVPKATPAP--KKAEADNPKTKPLALQ--------K 80

Human  6228 ATPLPVTSLSSVSTGHATPLAVSSATSASTVSSDSPLKM------------ETSGMTTPSLKTDG 6280
            .|.:||..:||..|           ....||:...|.||            |...:.......|.
  Fly    81 PTLIPVVHVSSRGT-----------DDILTVAGLKPEKMFGALIMPNDYLGELYDVDNSGYNWDP 134

Human  6281 GRRTATSPPPTTSQTIIS--TIPSTAMHTRSTAAPIPILPERGVSLF----PYGADAGDLEF--- 6336
            ....|   ||||..|...  ||         |||.:..|....:..:    .||. .||.:|
  Fly   135 NNNVA---PPTTYSTAAGGYTI---------TAARLAELRSNFMYWYFDKDMYGG-RGDYQFDIH 186

Human  6337 -----VRRTVDFTSPLFKPATGFPLG---SSLRDSLYFTDNGQ-----IIFPESDYQIFSYPNPL 6388
                 :.:.::|..|.:    ||...   .||...|.|:|..:     ::||..|:.....|:.:
  Fly   187 ASMTQLHKNLNFQLPFY----GFRFNYTRLSLNGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFM 247

Human  6389 PTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGGYKAR- 6452
            .. |..:..|..:.|  .|.|..| .|..|                :.|..:...|:..|.:.|
  Fly   248 GI-FFSKCRVGRIYP--SDIDQRT-PGVYF----------------RVERDLMGRTDRFGVEVRE 292

Human  6453 ---WALKV------TWVNAHAYPAQW------------TLGSNTYQAILSTDGSRSYALFLY--- 6493
               |.::.      |::..|...|.|            ...:||:|.:|:||...:|.:|.|
  Fly   293 RTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGGIDNSLYTTNTFQMVLATDEVYTYIIFNYAVL 357

Human  6494 ------QSGGMQWDVAQRSGN-PVLMGFSSGDG--------YFENS------------------- 6524
                  ::||   |..:..|. |..:||::|:|        |.:|.
  Fly   358 NWLSHTEAGG---DTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNMVIRDLANRGWANGFPGRHI 419

Human  6525 ---------------------PLMSQP-------------------------------------- 6530
                                 ||...|
  Fly   420 FRVDEQILIGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIRVTCHFDTESVLGTYV 484

Human  6531 ----------------------------------------------------------------V 6531
                                                                            .
  Fly   485 DRNRVICVQPYLKAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRIT 549

Human  6532 WERYR--------------------------------------------PDRFLNSNSGLQGLQF 6552
            |.:|.                                            |..::|.|:..:.:||
  Fly   550 WNQYNLTSNANANVMISLWGYRETKIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQF 614

Human  6553 -------------------------------YRLHREERPN----YRLECLQWLKSQPRWPSWGW 6582
                                           |...:.||.:    .|..|..|:::.....::..
  Fly   615 GFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARALCDNWIRADRFLRNFAA 679

Human  6583 NQVSCPCSWQQGRRDL-RFQP----------------------VSIGRWGLGSRQLCSFTSWRGG 6624
            :...|||:..|...|. ||:|                      ||......|:.|.|.:..: |.
  Fly   680 DLPLCPCTLDQAVLDKGRFRPDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCYDRY-GF 743

Human  6625 VCCSYGP-WGEFREGWH--VQRPWQLAQELEPQS-W---------CCRWNDKPYL-CALYQ-QRR 6674
            :..:|.. ||......|  .:.||..|.::...| |         ||.|.::..: |..|: :||
  Fly   744 LMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERR 808

Human  6675 PHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQT-----G 6734
            |...|..|:.|..|.:|||||..|.||.:|||||||:|:|..:.|.::.|.:|||..|.     |
  Fly   809 PSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYG 873

Human  6735 SAQATNFIAFAAQYRSSS-----LGPVTVQW---LLEPHDAIRVLLDNQTVTFQPDHEDGGGQET 6791
            ..:||...|.|.:..:::     |.|:..:|   |....|..||..|.:::.||  |.|  |...
  Fly   874 EVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQ--HFD--GVTV 934

Human  6792 FNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRM 6856
            :..|.:|   |.|:|...||....|.|:.....:.....||.::.|:|.||.|.|:.|..|||.:
  Fly   935 YTPTYLL---NQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFML 996

Human  6857 PNGSTIPPGSPEEMLFH--FGMTW-----QINGTG-LLGKR----------------NDQL-PSN 6896
            |||........:....|  ||:.|     ::.|.| .|.||                |..| |::
  Fly   997 PNGQVAQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGRMSGYYANATFQPNYVLDPAD 1061

Human  6897 FTPVFYSQLQKNSSW----AEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQ 6957
            |.|.       |.|:    ||.|...|   ..|.||             ..::.|.:.|:.|.|.
  Fly  1062 FLPA-------NRSYDLERAEELCGEC---MQCQYD-------------YAMTLNRDLAHFTKNY 1103

Human  6958 YPPSIN 6963
            |...:|
  Fly  1104 YDTIVN 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUC4	NP_001309397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..291
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..969
		NIDO	6403..6560	CDD:214712	46/413 (11%)
		AMOP	6559..6674	CDD:128962	33/156 (21%)
		VWD	6679..6859	CDD:214566	67/192 (35%)
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	35/181 (19%)
		AMOP	660..805	CDD:281737	31/145 (21%)
		VWD	811..999	CDD:214566	67/194 (35%)
		CCP	1121..1171	CDD:214478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020