DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUC4 and K03H1.5

DIOPT Version :9

Sequence 1:	NP_001309397.1	Gene:	MUC4 / 4585	HGNCID:	7514	Length:	7418	Species:	Homo sapiens
Sequence 2:	NP_499205.1	Gene:	K03H1.5 / 176404	WormBaseID:	WBGene00010540	Length:	1385	Species:	Caenorhabditis elegans

Alignment Length:	764	Identity:	160/764 - (20%)
Similarity:	254/764 - (33%)	Gaps:	255/764 - (33%)

- Green bases have known domain annotations that are detailed below.

Human  6442 KMTNNGGYKARWALKVTWVNAHAYPA-------------QW--------TLGSNTYQAILSTDGS 6485
            :|:.:||....:..|...||:...||             :|        .||........:|...
Worm   527 RMSRDGGQSFPFFGKFYVVNSERAPASVSLKDSVDNKTNRWYEPYAQELALGWQAMNLTWNTGAR 591

Human  6486 RSYALFLYQSGGMQWDVAQRSG----NPVLMGFSSGDGY-FENSPLMSQ----PVWERY------ 6535
            ...:||.|      |:.|.||.    :.:..|.|:...| |....|..|    ..|:::
Worm   592 VDISLFGY------WEDADRSHFERIDYLARGISNTGSYSFRPQQLTKQFLLRDAWQKFHFGFVQ 650

Human  6536 -------------RPDRFLNSNSGLQGLQFYRLHREER---PNYRLE-CLQWLKSQPRWPSWGWN 6583
                         :|..|          .:|.||..||   .|:.:: |::|.:...:..::
Worm   651 VALADAEDGVMWSKPTPF----------PWYHLHEWERYYGRNWPIDMCIEWFEYDGKRNNF--- 702

Human  6584 QVS------CPCSWQQGRRDL-RFQPV----------------------SIGRWGLGSRQLCSFT 6619
            |:.      |||...|...|| ||.|:                      |:.....||.|.|
Worm   703 QIDLTTDFPCPCKLPQAMLDLGRFMPIMDCDKDGDTSCPFNKGAQHCIQSVQPTFSGSSQQC--- 764

Human  6620 SWRGGVCCSYGPWGEFREGW--------------------HVQRPWQLAQ----------ELEPQ 6654
                  |..|..:..|.:.|                    :...|::|..          :|.|.
Worm   765 ------CYDYDGYLMFTDDWEPDGDYTTFFQPGTPARAHRYGAAPYRLPPFIPTLSNYQLDLNPY 823

Human  6655 SWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQD 6719
            ..||::.|.   |..|..||...||..||.|...:::|:||:.|.||:.||..|.|.::|..:..
Worm   824 RTCCKYADH---CEFYYWRRMTNGCQDYRAPAAGYIYGEPHVITYDGIRYTMPGKGYYVLTMSDS 885

Human  6720 GNSSFLLQGRTAQT------GSAQATNFIAFAAQYRSSSLGPVTV-----QWLLEPHDAIRVLLD 6773
            .....::|.|..|.      ....||.....|.|...||:..|..     :|.....    |.:|
Worm   886 PYHKLMVQVRLEQPDDTLWHAHVNATVITGVAVQENDSSIVQVYARKPMRRWRYRTD----VYVD 946

Human  6774 NQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEY--- 6835
            .....|...|......:..:....|.:.|.||:.........:.:.....:|....:|||.|
Worm   947 GTRRFFDKPHWKHQQFKHLDIRNPLQNMNQSEIVIMLKSGVGIRIFEGFGMLDVMVTLPPSYNTT 1011

Human  6836 ----------------QNR---TEGLLGVWNNNPEDDFRMPNGSTIPPGSP------EEMLF-HF 6874
                            |.|   |.||||.:||:|.||...|:|:.....:|      .:|:: .|
Worm  1012 CRPGESLSSSLNAPRGQRRCYTTLGLLGTYNNDPADDLTTPSGTVTRVQNPTTTASTTQMIYEQF 1076

Human  6875 GMTWQINGTGLLGKRNDQL-------------------PSNFTPVFYSQ-LQKNSS---WAEHLI 6916
            ...|:|:||      ||::                   .|::.||::.| :..|:|   ..|.::
Worm  1077 ASFWKIDGT------NDKIGGVLFQDKFKPIYNPLLFAESDYRPVYWPQTIDMNASRVFTMEQVV 1135

Human  6917 SNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANAT----------------LNQYPPSIN-- 6963
            |.|..:..|.||.:......:||.|....|.:.....|                :.:.||:.|
Worm  1136 STCQNNPECEYDFIMTGRKEVGLTTLRRQKEFFALQKTGSKQLISCGPLLKKEGVVKTPPAANYL 1200

Human  6964 -GGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLE-LFENGTLLWTP 7010
             |.:|:.:.|.     :|..:.            |:| :..|||  |:|
Worm  1201 DGDKVVFSCKP-----KYYIHG------------DIERVCRNGT--WSP 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUC4	NP_001309397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..291
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..969
		NIDO	6403..6560	CDD:214712	31/166 (19%)
		AMOP	6559..6674	CDD:128962	33/177 (19%)
		VWD	6679..6859	CDD:214566	52/212 (25%)
K03H1.5	NP_499205.1	NIDO	286..452	CDD:214712
		IPT	468..>527	CDD:214657	160/764 (21%)
		AMOP	681..840	CDD:128962	31/173 (18%)
		VWD	855..1055	CDD:295339	48/203 (24%)
		CCP	1181..1230	CDD:153056	13/67 (19%)
		zf-C4H2	<1270..1371	CDD:287156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161449379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950