DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cpo and RBPMS

DIOPT Version :9

Sequence 1:	NP_001014632.3	Gene:	cpo / 45840	FlyBaseID:	FBgn0263995	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_016868469.1	Gene:	RBPMS / 11030	HGNCID:	19097	Length:	264	Species:	Homo sapiens

Alignment Length:	250	Identity:	107/250 - (42%)
Similarity:	137/250 - (54%)	Gaps:	51/250 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 NSNSNAIMENQMALAPLGLSQSMDSVNTASNEEEVRTLFVSGLPMDAKPRELYLLFRAYEGYEGS 471
            |:...|..||..:.|.|             .|||||||||||||:|.||||||||||.::|||||
Human     2 NNGGKAEKENTPSEANL-------------QEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGS 53

  Fly   472 LLKVTSKNGKTASPVGFVTFHTRAGAEAAKQDLQGVRFDPDMPQTIRLEFAKSNTKVSKPK---- 532
            |:|:|||     .|||||:|.:|:.|||||..|.|:||||::|||:||||||:|||::|.|
Human    54 LIKLTSK-----QPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGT 113

  Fly   533 PQPNTATTASHPALMHPLTGHLGGP-FFPGGPELW-HHPLAYSAAAAAELPGAA----ALQHATL 591
            |.|:|....:.|..:......|..| .:|..||:| .:|| |.|..|..||..|    |..||.:
Human   114 PNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPL-YPAELAPALPPPAFTYPASLHAQV 177

  Fly   592 VHP-----ALHPQVPVRSYLXLN---------TDKVMEQPMHQTQM-----TMPP 627
            ..|     ||.|: ||.|:| ..         ..|.::  |||...     ::||
Human   178 SSPPPAMGALCPR-PVLSHLSQEGSSNSALCLVSKWIQ--MHQAMSRGCAGSLPP 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cpo	NP_001014632.3	RRM	<428..>525	CDD:223796	61/96 (64%)
		RRM_cpo	441..523	CDD:241128	56/81 (69%)
		RRM_scw1_like	712..819	CDD:240691
RBPMS	XP_016868469.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7852
eggNOG	1	0.900	-	-		E1_KOG1457
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4385
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002113
OrthoInspector	1	1.000	-	-		otm41893
orthoMCL	1	0.900	-	-		OOG6_104919
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3149
SonicParanoid	1	1.000	-	-		X1401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.650