Protein Alignment bur and guaA

DIOPT Version :10

• Sequence 1: NP_620114.3
• Gene: bur / 45830
• FlyBaseID: FBgn0000239
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_417002.1
• Gene: guaA / 947334
• ECOCYCID: EG10420
• Length: 525
• Species: Escherichia coli
• Alignment Length: 686
• Identity: 221/686 - (32%)
• Similarity: 312/686 - (45%)
• Gaps: 176/686 - (25%)

  Fly    11 ENGLRHDKIVILDAGAQYGKVIDRKVRELFVETDILPLDTPAATIRNNGYRGIIISGGPNSVYAE 75
            ||..:| :|:|||.|:||.:::.|:||||.|..::...|...|.||:....|||:||||.|...|
E. coli     3 ENIHKH-RILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEE 66

  Fly    76 DAPSYDPDLFKLKIPMLGICYGMQLINKEFGGTVLKKDVREDGQQNIEIETSCPLFSRLSRTQS- 139
            ::|.....:|:..:|:.|:|||||.:..:.||.|...:.||.|...:|:.....|...:....:
E. coli    67 NSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTA 131

  Fly   140 -------VLLTHGDSVERVGENLKIGGWSTNRIVTAIY-NEVLRIYGVQFHPEVDLTINGKQMLS 196
                   |.::|||.|..:..:. |...||.....||. ||..|.|||||||||..|..|.:||.
E. coli   132 DGKPLLDVWMSHGDKVTAIPSDF-ITVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLE 195

  Fly   197 NFLYEICELTPNFTMGSRKEECIRYIREKVGNNKVLLLVSGGVDSSVCAALLRRALYPHQIIAVH 261
            .|:.:||:....:|.....::.:..|||:||::||:|.:||||||||.|.||.||: ...:..|.
E. coli   196 RFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAI-GKNLTCVF 259

  Fly   262 VDNGFMRKKESEKVERSLRD-IGIDLIVRKEGYTFLKGTTQVKRPGQYSVVETPMLCQTYNPEEK 325
            ||||.:|..|:|:|.....| .|::::.......||..                 |....:||.|
E. coli   260 VDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSA-----------------LAGENDPEAK 307

  Fly   326 RKIIGDIFVKVTNDVVAELKLKPEEV-MLAQGTLRPDLIESASSMVSTNAETIKTHHNDTDLIRE 389
            |||||.:||:|.:    |..||.|:| .|||||:.||:||||:| .:..|..||:|||...|.:|
E. coli   308 RKIIGRVFVEVFD----EEALKLEDVKWLAQGTIYPDVIESAAS-ATGKAHVIKSHHNVGGLPKE 367

  Fly   390 LRNAGRVVEPLCDFHKDEVRDLGNDLGLPQELVERQPFPGPGLAIRVLCAEEAYMEKDYSETQVI 454
            ::..  :||||.:..|||||.:|.:||||.:::.|.|||||||.:|||    ..::|:|.:
E. coli   368 MKMG--LVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVL----GEVKKEYCD---- 422

  Fly   455 IRVIVDYKNKLQKNHALINRVTAA-TSEAEQKDLMRISSNSQIQATLLPIRSVGVQGDKRSYSYV 518
                            |:.|..|. ..|..:.||  ....||.....||:|||||.||.|.|.:|
E. coli   423 ----------------LLRRADAIFIEELRKADL--YDKVSQAFTVFLPVRSVGVMGDGRKYDWV 469

  Fly   519 VGLSTSQEPNWQDLLFLAKIIPRILHNVNRVCYIFGEPVQYLVTDITHTTLNTVVLSQLRQADDI 583
            |.
E. coli   470 VS--------------------------------------------------------------- 471

  Fly   584 ANEIIMQAGLYRKISQMPVVLIPVHFDRDPINRTPSCRRSVVLRPFITNDFMTGVPAEPGSVQMP 648
                                                      ||...|.||||...|     .:|
E. coli   472 ------------------------------------------LRAVETIDFMTAHWA-----HLP 489

  Fly   649 LQVLNQIV-RDISKLDGISRVLYDLTAKPPGTTEWE 683
            ...|.::. |.|::::|||||:||::.|||.|.|||
E. coli   490 YDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bur	NP_620114.3	guaA	16..683	CDD:234614	217/679 (32%)
		GMP_synt_C	494..551	CDD:425963	15/56 (27%)
guaA	NP_417002.1	guaA	5..525	CDD:234614	217/682 (32%)