Protein Alignment bur and GUA1

DIOPT Version :9

• Sequence 1: NP_001286120.1
• Gene: bur / 45830
• FlyBaseID: FBgn0000239
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_013944.1
• Gene: GUA1 / 855257
• SGDID: S000004830
• Length: 525
• Species: Saccharomyces cerevisiae
• Alignment Length: 697
• Identity: 225/697 - (32%)
• Similarity: 327/697 - (46%)
• Gaps: 195/697 - (27%)

  Fly     3 SNIFLGTAENGLRHDKIVILDAGAQYGKVIDRKVRELFVETDILPLDTPAATIRNNGY--RGIII 65
            ||:|          |.|::||.|:||..:|.|::||..:..::||.   ...|...|:  :|:|:
Yeast     8 SNMF----------DTILVLDFGSQYSHLITRRLREFNIYAEMLPC---TQKISELGWTPKGVIL 59

  Fly    66 SGGPNSVYAEDAPSYDPDLFKLKIPMLGICYGMQLINKEFGGTVLKKDVREDGQQNIE-IETSCP 129
            ||||.||||||||..|..:|.|.:|:||||||||.:....|..|.:.|.||.|...:: |:.|..
Yeast    60 SGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNS 124

  Fly   130 LFSRLSRTQSVLLTHGDSVERVGENLKIGGWSTNRIVTAIYNEVLRIYGVQFHPEVDLTINGKQM 194
            ||..:: ..:|.::|||.:..:....|....|.|.....|.:|...|||:||||||..:..||.:
Yeast   125 LFKGMN-DSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTL 188

  Fly   195 LSNFLYEICELTPNFTMGSRKEECIRYIREKVG-NNKVLLLVSGGVDSSVCAALLRRALYPHQII 258
            |.||..::|....|:||.:..:..|..||:.|| ..:|:..|||||||:|.:.|:..|: ..:..
Yeast   189 LKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAI-GDRFH 252

  Fly   259 AVHVDNGFMRKKESEKVERSL-RDIGIDLIV---RKEGYTFLKGTTQVKRPGQYSVVETPMLCQT 319
            |:.||||.:|..|:..|:::| ..:||:|:|   .:|..:.|||.|
Yeast   253 AILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVT------------------- 298

  Fly   320 YNPEEKRKIIGDIFVKVTNDVVAELKLKPEE----VMLAQGTLRPDLIESASSMVSTNAETIKTH 380
             :||:||||||:.|:.|. :..|| |:||::    ..|.||||.||:|||.|  ....::|||||
Yeast   299 -DPEKKRKIIGNTFIHVF-EREAE-KIKPKDGKEIQFLLQGTLYPDVIESIS--FKGPSQTIKTH 358

  Fly   381 HNDTDLIRELRNAGRVVEPLCDFHKDEVRDLGNDLGLPQELVERQPFPGPGLAIRVLCAEEAYME 445
            ||...|:..::.  :::|||.:..|||||.||..||:|.:||.|.||||||:|||||
Yeast   359 HNVGGLLENMKL--KLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVL-------- 413

  Fly   446 KDYSETQVIIRVIVD--YKNKLQKNHALINRVTAATSEAEQKDLMRISSNSQIQATLLPIRSVGV 508
            .:.::.||.|....|  |..:::| ..|.|::                  ||..|.|||::||||
Yeast   414 GEVTKEQVEIARKADNIYIEEIKK-AGLYNQI------------------SQAFACLLPVKSVGV 459

  Fly   509 QGDKRSYSYVVGLSTSQEPNWQDLLFLAKIIPRILHNVNRVCYIFGEPVQYLVTDITHTTLNTVV 573
            .||:|:|..|
Yeast   460 MGDQRTYDQV------------------------------------------------------- 469

  Fly   574 LSQLRQADDIANEIIMQAGLYRKISQMPVVLIPVHFDRDPINRTPSCRRSVVLRPFITNDFMTG- 637
                                                              :.||...|.||||.
Yeast   470 --------------------------------------------------IALRAIETTDFMTAD 484

  Fly   638 -VPAEPGSVQMPLQVLNQIVRDISKLDGISRVLYDLTAKPPGTTEWE 683
             .|.|...::   :|.::||.::   ||::||.||:|:|||.|.|||
Yeast   485 WFPFEHSFLK---KVASRIVNEV---DGVARVTYDITSKPPATVEWE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bur	NP_001286120.1	guaA	16..683	CDD:234614	220/682 (32%)
		GATase1_GMP_Synthase	19..199	CDD:153213	72/182 (40%)
		GMP_synthase_C	230..682	CDD:238955	136/463 (29%)
GUA1	NP_013944.1	guaA	9..525	CDD:234614	222/694 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346715
Domainoid	1	1.000	118	1.000	Domainoid score	I1288
eggNOG	1	0.900	-	-		E1_COG0519
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I591
Isobase	1	0.950	-	0	Normalized mean entropy	S1429
OMA	1	1.010	-	-		QHG60613
OrthoFinder	1	1.000	-	-		FOG0004108
OrthoInspector	1	1.000	-	-		oto99656
orthoMCL	1	0.900	-	-		OOG6_100862
Panther	1	1.100	-	-	LDO	PTHR11922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R534
SonicParanoid	1	1.000	-	-		X2849
TreeFam	1	0.960	-	-
	15	14.740