DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bur and gmps

DIOPT Version :9

Sequence 1:	NP_001286120.1	Gene:	bur / 45830	FlyBaseID:	FBgn0000239	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_956881.2	Gene:	gmps / 393559	ZFINID:	ZDB-GENE-040426-1503	Length:	692	Species:	Danio rerio

Alignment Length:	684	Identity:	401/684 - (58%)
Similarity:	516/684 - (75%)	Gaps:	11/684 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGTAENGL--RHDKIVILDAGAQYGKVIDRKVRELFVETDILPLDTPAATIRNNGYRGIIISGGP 69
            :|..::||  ....:|||||||||||||||:|||:||:::||||:|||..||..|:|.|||||||
Zfish    13 VGEPKDGLCSYEGAVVILDAGAQYGKVIDRRVREMFVQSEILPLETPAFAIREQGFRAIIISGGP 77

  Fly    70 NSVYAEDAPSYDPDLFKLKIPMLGICYGMQLINKEFGGTVLKKDVREDGQQNIEIETSCPLFSRL 134
            |||||||||.:||.:|.:..|:||||||||::||.|||||.:|.|||||..||.::.||.||..|
Zfish    78 NSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHRKSVREDGVFNIALDNSCSLFRGL 142

  Fly   135 SRTQSVLLTHGDSVERVGENLKIGGWSTNRIVTAIYNEVLRIYGVQFHPEVDLTINGKQMLSNFL 199
            .:.:.|||||||||::|.:..||...|.| ||..|.||..::||.|||||||||..|..||.|||
Zfish   143 QKEEHVLLTHGDSVDKVADGFKIVAQSGN-IVAGIANEQKKLYGTQFHPEVDLTERGMDMLRNFL 206

  Fly   200 YEICELTPNFTMGSRKEECIRYIREKVGNNKVLLLVSGGVDSSVCAALLRRALYPHQIIAVHVDN 264
            :||...:.|||:.:|:..|||.|||||..:|||:|:||||||:||.|||.:||...|:||||:||
Zfish   207 FEIAGCSSNFTVQNRQMSCIREIREKVDKSKVLVLLSGGVDSTVCTALLNKALNQEQVIAVHIDN 271

  Fly   265 GFMRKKESEKVERSLRDIGIDLIVRKEGYTFLKGTT-----QVKRPGQYSVVETPMLCQTYNPEE 324
            |||||:||:.||.:|..:||.|.|....:||..|||     :..|..:..:.:|  |..|.||||
Zfish   272 GFMRKRESQSVEEALTKLGIKLKVVNAAHTFYNGTTTLPISEEDRTPRKRISKT--LNMTTNPEE 334

  Fly   325 KRKIIGDIFVKVTNDVVAELKLKPEEVMLAQGTLRPDLIESASSMVSTNAETIKTHHNDTDLIRE 389
            |||||||.||||.|:|:.|:.||||:|.|||||||||||||||.:.|..||.||||||||:|||:
Zfish   335 KRKIIGDTFVKVANEVIGEMNLKPEDVYLAQGTLRPDLIESASHLASGKAEVIKTHHNDTELIRK 399

  Fly   390 LRNAGRVVEPLCDFHKDEVRDLGNDLGLPQELVERQPFPGPGLAIRVLCAEEAYMEKDYSETQVI 454
            ||:.|:|:|||.||||||||.||.:||||:|:|.|.|||||||||||:||:|.|:.||::||..|
Zfish   400 LRDEGKVIEPLKDFHKDEVRALGRELGLPEEIVSRHPFPGPGLAIRVICADEPYVCKDFAETNNI 464

  Fly   455 IRVIVDYKNKLQKNHALINRVTAATSEAEQKDLMRISSNSQIQATLLPIRSVGVQGDKRSYSYVV 519
            :::|.|:...::|.|.|:.||.:..|:.|::.||:|:|...:.|.||||::||||||.||||||.
Zfish   465 LKIITDFSASVKKPHTLLQRVKSCISDEEEEKLMQITSLHSLNAFLLPIKTVGVQGDSRSYSYVC 529

  Fly   520 GLSTSQEPNWQDLLFLAKIIPRILHNVNRVCYIFGEPVQYLVTDITHTTLNTVVLSQLRQADDIA 584
            |:|:.:.|:|..|:|||::||||.|::|||.|:||..|:...||||.|.|.|.|||.|||||.:|
Zfish   530 GVSSKEAPHWDSLMFLARLIPRICHSINRVVYVFGSHVKEPPTDITPTFLTTGVLSTLRQADFVA 594

  Fly   585 NEIIMQAGLYRKISQMPVVLIPVHFDRDPINRTPSCRRSVVLRPFITNDFMTGVPAEPGSVQMPL 649
            :.|:.::|...|||||||:|.|:||||||:.:.||||||||:|.|||:|||||:.|.|.: |:|.
Zfish   595 HSILRESGYSSKISQMPVILTPLHFDRDPLQKQPSCRRSVVIRTFITSDFMTGIAATPDN-QIPE 658

  Fly   650 QVLNQIVRDISKLDGISRVLYDLTAKPPGTTEWE 683
            :|:.::|.:|.|:.|||||:||||:|||||||||
Zfish   659 EVVLKMVNEIKKIPGISRVMYDLTSKPPGTTEWE 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bur	NP_001286120.1	guaA	16..683	CDD:234614	396/671 (59%)
		GATase1_GMP_Synthase	19..199	CDD:153213	113/179 (63%)
		GMP_synthase_C	230..682	CDD:238955	266/456 (58%)
gmps	NP_956881.2	guaA	27..692	CDD:234614	396/668 (59%)
		GATase1_GMP_Synthase	27..206	CDD:153213	113/179 (63%)
		GMP_synthase_C	237..691	CDD:238955	266/456 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596574
Domainoid	1	1.000	231	1.000	Domainoid score	I2371
eggNOG	1	0.900	-	-		E1_COG0519
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68367
Inparanoid	1	1.050	787	1.000	Inparanoid score	I498
OMA	1	1.010	-	-		QHG60613
OrthoDB	1	1.010	-	-		D302109at33208
OrthoFinder	1	1.000	-	-		FOG0004108
OrthoInspector	1	1.000	-	-		oto40322
orthoMCL	1	0.900	-	-		OOG6_100862
Panther	1	1.100	-	-	LDO	PTHR11922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R534
SonicParanoid	1	1.000	-	-		X2849
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800