Protein Alignment bur and gua2

DIOPT Version :10

• Sequence 1: NP_620114.3
• Gene: bur / 45830
• FlyBaseID: FBgn0000239
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_594312.1
• Gene: gua2 / 2542573
• PomBaseID: SPAP7G5.02C
• Length: 539
• Species: Schizosaccharomyces pombe
• Alignment Length: 694
• Identity: 208/694 - (29%)
• Similarity: 307/694 - (44%)
• Gaps: 200/694 - (28%)

  Fly    17 DKIVILDAGAQYGKVIDRKVRELFVETDILPLD-----TPAATIRNNGYRGIIISGGPNSVYAED 76
            |.|:|||.|:||..:|.|::||:.|..::||..     .|...|      |:|:||||.|||.:.
pombe    19 DTILILDFGSQYSHLIARRLREIHVYAELLPCTQKIEALPFKPI------GVILSGGPYSVYDDI 77

  Fly    77 APSYDPDLFKLKIPMLGICYGMQL------------INKEFGGTVLKKDVREDGQQNIEIETSCP 129
            ||..||.:|:|.:|:||||||||.            |.:|:|...:..      :..|:.|....
pombe    78 APHVDPAVFELGVPVLGICYGMQEIAWLNGRCVEPGIEREYGPATVSM------EPEIKTEVFKS 136

  Fly   130 LFSRLSRTQSVLLTHGDSVERVGENLKIGGWSTNRIVTAIYNEVLRIYGVQFHPEVDLTINGKQM 194
            .|:.:.:...|.::|||.:..:....:..|.:.|.....|.:....|.|:||||||..|..|.|:
pombe   137 FFNSMPKEFEVWMSHGDRLSALPNGYETIGRTKNSPFAVIAHVTKPIIGLQFHPEVTHTPLGLQL 201

  Fly   195 LSNFLYEICELTPNFTMGSRKEECIRYIREKVG-NNKVLLLVSGGVDSSVCAALLRRALYPHQII 258
            :.||..|||...||::|.:..::.|..||:.:| ::.|:..|||||||:|.:.:|:.|: ..:..
pombe   202 IKNFAIEICHAKPNWSMENFVDKEILRIRKMIGPSDHVIGAVSGGVDSTVASKVLKEAI-GDRFH 265

  Fly   259 AVHVDNGFMRKKESEKVERSL-RDIGIDLIVRKEGYTF---LKGTTQVKRPGQYSVVETPMLCQT 319
            |:.||||.:|..|:|.|..:| :.:||.|.|......|   |||.|
pombe   266 AIMVDNGLLRLNEAEIVRETLNKHLGIQLTVVDASEEFIGKLKGVT------------------- 311

  Fly   320 YNPEEKRKIIGDIFVKV----TNDVVAELKLKPEEVMLAQGTLRPDLIESASSMVSTNAETIKTH 380
             :||:||||||:.|:.|    ...:|.|...|.|  .|.||||.||:|||.|  ....::|||||
pombe   312 -DPEKKRKIIGNTFIHVFEREAERIVKETNGKVE--YLLQGTLYPDVIESIS--FKGPSQTIKTH 371

  Fly   381 HNDTDLIRELRNAGRVVEPLCDFHKDEVRDLGNDLGLPQELVERQPFPGPGLAIRVLC-AEEAYM 444
            ||...|:::::.  :::|||.:..|||||.||..||:...||.|.|||||||.||:|. ...|.:
pombe   372 HNVGGLLKDMKL--KLIEPLRELFKDEVRALGELLGIEHSLVWRHPFPGPGLGIRILGEVNAAQL 434

  Fly   445 EKDYSETQVIIRVIVDYKNKLQKNHALINRVTAATSEAEQKDLMRISSNSQIQATLLPIRSVGVQ 509
            |.......:.|..|        :||...:::                  ||..|.|||:::|||.
pombe   435 EIARKADHIFITEI--------RNHGYYDKI------------------SQAFAALLPVKAVGVM 473

  Fly   510 GDKRSYSYVVGLSTSQEPNWQDLLFLAKIIPRILHNVNRVCYIFGEPVQYLVTDITHTTLNTVVL 574
            ||||::..|
pombe   474 GDKRTHEQV-------------------------------------------------------- 482

  Fly   575 SQLRQADDIANEIIMQAGLYRKISQMPVVLIPVHFDRDPINRTPSCRRSVVLRPFITNDFMTGVP 639
                                                             :.||...|:||||...
pombe   483 -------------------------------------------------IALRAITTSDFMTADW 498

  Fly   640 AEPGSVQMPLQVLNQIVRDISKLDGISRVLYDLTAKPPGTTEWE 683
            .:..|::....|.::|..::|   |::|||||:::|||.|.|.|
pombe   499 YDGFSIKFLKLVSSRICNEVS---GVNRVLYDISSKPPATVEME 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bur	NP_620114.3	guaA	16..683	CDD:234614	207/692 (30%)
		GMP_synt_C	494..551	CDD:425963	14/56 (25%)
gua2	NP_594312.1	guaA	19..539	CDD:234614	207/692 (30%)