DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and DDX3Y

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001116137.1	Gene:	DDX3Y / 8653	HGNCID:	2699	Length:	660	Species:	Homo sapiens

Alignment Length:	807	Identity:	409/807 - (50%)
Similarity:	494/807 - (61%)	Gaps:	157/807 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNAINQNGTGLEQQVAGLDLNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAES 65
            ||:.:.:|...|:||:|.||||  |...||      ..::.:.|.|:|||||....:....|.:|
Human     1 MSHVVVKNDPELDQQLANLDLN--SEKQSG------GASTASKGRYIPPHLRNREASKGFHDKDS 57

  Fly    66 QGQGQGQGQGFDSRSGNPRQETRDPQQSRGGGGEY-RRGGGGGGRGFNRQSGDYGYGSGGGGR-R 128
            .|....:.:...|..|     :||   |||..|.: .||.|..||..:|...||   .|.|.| |
Human    58 SGWSCSKDKDAYSSFG-----SRD---SRGKPGYFSERGSGSRGRFDDRGRSDY---DGIGNRER 111

  Fly   129 GGGGRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNEQTAEDGQAQQ 193
            .|.||||                 |||                      .|...:::.||.
Human   112 PGFGRFE-----------------RSG----------------------HSRWCDKSVEDD---- 133

  Fly   194 QQQPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKEGGGSNVDYTKLGARD 258
                    |.:|..|:
Human   134 --------WSKPLPPS------------------------------------------------- 141

  Fly   259 ERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQK 323
            ||||.|||..|||||||:||:||||||||.|.||:|.:|.|:.:.|||..|:.|.||.:||||||
Human   142 ERLEQELFSGGNTGINFEKYDDIPVEATGSNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQK 206

  Fly   324 HAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTR------QYSRRKQYPLGL 382
            ||||||...||||||||||||||||||:|||:|:|..|   |.::.:      :|.||||||:.|
Human   207 HAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDG---PGEALKAVKENGRYGRRKQYPISL 268

  Fly   383 VLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGK 447
            |||||||||.||:|||:||:||||:||.|:|||.:..:|:|:|:|||||:|||||||.||:.|||
Human   269 VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGK 333

  Fly   448 VGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFLSNY 512
            :||:..::||||||||||||||||||||||||..|||.|.|.|:||||||||:||.||.|||..|
Human   334 IGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEY 398

  Fly   513 IFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEE 577
            |||||||||||||||||.::||.:.||||:|||:|.:.      ..|||||:||||||||||||:
Human   399 IFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILGAT------GSDSLTLVFVETKKGADSLED 457

  Fly   578 FLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEE 642
            |||...:..|||||||:|::|||||..||||..|||||||||||||||.:|:||||||||||:||
Human   458 FLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEE 522

  Fly   643 YVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAKRAGRG 707
            ||||||||||:||||:|||||||||.||..|||:||:|.|||:||::|:|:.:..:.|..| ||.
Human   523 YVHRIGRTGRVGNLGLATSFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSR-GRS 586

  Fly   708 GGGRYGGGFGSRDYRQSSGGGGGGRSGPPPRSGGSGSGGGGGSYRSNGNSYGKFGGNSGGGGYYG 772
            ...|:.||||:||||||||....|...    |.||.|..|||.|   |||.|     .|||| ||
Human   587 KSNRFSGGFGARDYRQSSGSSSSGFGA----SRGSSSRSGGGGY---GNSRG-----FGGGG-YG 638

  Fly   773 GGAGGGSYGGSYGGGSASHSSNAPDWW 799
            |......|||:|       :|...|||
Human   639 GFYNSDGYGGNY-------NSQGVDWW 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	150/224 (67%)
		DEXDc	315..529	CDD:214692	155/219 (71%)
		Helicase_C	538..654	CDD:278689	83/115 (72%)
DDX3Y	NP_001116137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		50/155 (32%)
		PTZ00424	171..554	CDD:185609	269/391 (69%)
		Q motif	178..206		13/27 (48%)
		DEADc	180..402	CDD:238167	150/224 (67%)
		DEAD box	345..348		2/2 (100%)
		Helicase_C	424..534	CDD:278689	83/115 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..625		24/51 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	690	1.000	Inparanoid score	I695
Isobase	1	0.950	-	0	Normalized mean entropy	S391
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		otm40525
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2088
SonicParanoid	1	1.000	-	-		X820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.920