DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and DBP1

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_015206.1	Gene:	DBP1 / 855984	SGDID:	S000006040	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	800	Identity:	351/800 - (43%)
Similarity:	431/800 - (53%)	Gaps:	198/800 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LEQQVAGLDLNGGSADYSGPITSKTSTNSVTGG-----VYVPPHLRGGGGNNNAADAESQGQGQG 71
            |.|:|:.|.:|                |...||     .|||||||
Yeast     4 LPQKVSNLSIN----------------NKENGGGGGKSSYVPPHLR------------------- 33

  Fly    72 QGQGFDSRSGNPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGDYGYGSGGGGRRGGGGRFED 136
                  || |.|..|...|:|                                          ||
Yeast    34 ------SR-GKPSFERSTPKQ------------------------------------------ED 49

  Fly   137 NYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNEQTAEDGQAQQQQQPRNDR 201
            ...||:|..|.|    |..|..||..||.:..:     ||:.:|.|.
Yeast    50 KVTGGDFFRRAG----RQTGNNGGFFGFSKERN-----GGTSANYNR------------------ 87

  Fly   202 WQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKEGGGSNVDYTKLGARDERLEVELF 266
                               ||:.:|.:.|        :||.  .|.::.    |.::.:||.|||
Yeast    88 -------------------GGSSNYKSSG--------NRWV--NGKHIP----GPKNAKLEAELF 119

  Fly   267 GV------GNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQKHA 325
            ||      .::||.||.|::|||:|:|::||..|..|....|.|::..|:.||.:.|||||||::
Yeast   120 GVHDDPDYHSSGIKFDNYDNIPVDASGKDVPEPILDFSSPPLDELLMENIKLASFTKPTPVQKYS 184

  Fly   326 IPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSRRKQYPLGLVLAPTREL 390
            |||:..|||||||||||||||..||.|:..:::..|..|.|:..:.:..||.||..|||||||||
Yeast   185 IPIVTKGRDLMACAQTGSGKTGGFLFPLFTELFRSGPSPVPEKAQSFYSRKGYPSALVLAPTREL 249

  Fly   391 ATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGKVGLENIRF 455
            ||||||||:||.|||.:||.|:|||.....||||:||||.|:|||||||.|::.||||.|.||::
Yeast   250 ATQIFEEARKFTYRSWVRPCVVYGGAPIGNQMREVDRGCDLLVATPGRLNDLLERGKVSLANIKY 314

  Fly   456 LVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFLSNYIFLAVGRV 520
            |||||||||||||||||||.|||:.:||....|||||||||||..||.||.|||.|||||:||||
Yeast   315 LVLDEADRMLDMGFEPQIRHIVEECDMPSVENRQTLMFSATFPVDIQHLARDFLDNYIFLSVGRV 379

  Fly   521 GSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEEFLYQCNHP 585
            |||||||||.||:|.:.||:|.||||||:...|       |||||||||:.||.|.:||...|..
Yeast   380 GSTSENITQRILYVDDMDKKSALLDLLSAEHKG-------LTLIFVETKRMADQLTDFLIMQNFK 437

  Fly   586 VTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRT 650
            .|:|||||||.|||.||..|::....|||||||||||||||:|.||||:|||||:::||||||||
Yeast   438 ATAIHGDRTQAERERALSAFKANVADILVATAVAARGLDIPNVTHVINYDLPSDIDDYVHRIGRT 502

  Fly   651 GRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAKRAGRGGGGRYGG- 714
            ||.||.||||||||..|:||...|:|:|.|..||:|:|:.|:|.....||..   |||||.:..
Yeast   503 GRAGNTGVATSFFNSNNQNIVKGLMEILNEANQEVPTFLSDLSRQNSRGGRT---RGGGGFFNSR 564

  Fly   715 GFGSRDYRQSSGGGGGGRSGPPPRSGGSGSGGGGGSYRSNGNSYGKFGGNSGGGGYYGGGAGGGS 779
            ..||||||:..|.|..| |..|..:|.|..|..||.:|::....|
Yeast   565 NNGSRDYRKHGGNGSFG-STRPRNTGTSNWGSIGGGFRNDNEKNG-------------------- 608

  Fly   780 YGGSYGGGSASHSSNAPDWW 799
                ||..:||       ||
Yeast   609 ----YGNSNAS-------WW 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	139/218 (64%)
		DEXDc	315..529	CDD:214692	145/213 (68%)
		Helicase_C	538..654	CDD:278689	74/115 (64%)
DBP1	NP_015206.1	SrmB	129..595	CDD:223587	286/476 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I334
eggNOG	1	0.900	-	-		E2759_KOG0335
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I141
Isobase	1	0.950	-	0	Normalized mean entropy	S391
OMA	1	1.010	-	-		QHG53695
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		otm46566
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X820
TreeFam	1	0.960	-	-
	13	12.780