Protein Alignment bel and DDX43

DIOPT Version :10

• Sequence 1: NP_001262379.1
• Gene: bel / 45826
• FlyBaseID: FBgn0263231
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: XP_047274937.1
• Gene: DDX43 / 55510
• HGNCID: 18677
• Length: 653
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 199/583 - (34%)
• Similarity: 284/583 - (48%)
• Gaps: 100/583 - (17%)

  Fly   144 DSRRGGDWNRSG------GGGGGGRGFGRGPSYRGGG-------------------GGSGSNL-N 182
            :.|...:.||:|      |.||..||..|.|.....|                   |..||.: |
Human    28 ERRPAEELNRTGPEGYSVGRGGRWRGTSRPPEAVAAGHEELPLCFALKSHFVGAVIGRGGSKIKN 92

  Fly   183 EQTAEDGQAQ-QQQQPRN-----------------------------------DRWQEPERPAGF 211
            .|:..:...| .|:||.:                                   |...:|.  .|.
Human    93 IQSTTNTTIQIIQEQPESLVKIFGSKAMQTKAKAVIDNFVKKLEENYNSECGIDTAFQPS--VGK 155

  Fly   212 DGSEGGQSAGGNR---SYNNRGERGGGGYNSRWKEGGGSNVDYTKLGARD---ERLEVELFGVGN 270
            |||.......|:|   .::...|.|.....::|.:......::.|.....   .::|.:.:...|
Human   156 DGSTDNNVVAGDRPLIDWDQIREEGLKWQKTKWADLPPIKKNFYKESTATSAMSKVEADSWRKEN 220

  Fly   271 TGINFDKYEDIPVEATGQNVP-PNIT-SFDDV-QLTEIIRNNVALARYDKPTPVQKHAIPIIING 332
            ..|.:|..:|      |:..| ||.| :|||. |....:..|:..|.:.||||:|..|.||::.|
Human   221 FNITWDDLKD------GEKRPIPNPTCTFDDAFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQG 279

  Fly   333 RDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEE 397
            .||:..||||:|||..:|:|....:     |..|....|.:|    |..|||.||||||.|:..|
Human   280 IDLIGVAQTGTGKTLCYLMPGFIHL-----VLQPSLKGQRNR----PGMLVLTPTRELALQVEGE 335

  Fly   398 AKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGKVGLENIRFLVLDEAD 462
            ..|::|:. :|...:|||.|..||:.||.:|..:|:||||||.|:.....|.|:||.:|||||||
Human   336 CCKYSYKG-LRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEAD 399

  Fly   463 RMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFLSNYIFLAVGRVGSTS-EN 526
            :||||||||||.:|:  |::.|  .|||:|.|||:|..:..||..:|...:.:.||.:...: .:
Human   400 KMLDMGFEPQIMKIL--LDVRP--DRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSS 460

  Fly   527 ITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEEFLYQCNHPVTSIHG 591
            :.|.|:...|.:|.|::...|.|:      :.....::||..|..||.|...|...|..|.|:||
Human   461 VKQNIIVTTEEEKWSHMQTFLQSM------SSTDKVIVFVSRKAVADHLSSDLILGNISVESLHG 519

  Fly   592 DRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMG 654
            ||.|::||:||..|::|...||:||.:|:||||:..|.||.|||.|.::||||||||||||.|
Human   520 DREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc_DDX3	275..522	CDD:350809	106/249 (43%)
		SF2_C_DEAD	527..663	CDD:350174	57/128 (45%)
DDX43	XP_047274937.1	KH-I_DDX43_DDX53	69..134	CDD:411858	9/64 (14%)
		SrmB	242..>582	CDD:440279	155/359 (43%)