DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and ddx4

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	XP_012818309.1	Gene:	ddx4 / 549577	XenbaseID:	XB-GENE-1016809	Length:	678	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	303/735 - (41%)
Similarity:	408/735 - (55%)	Gaps:	139/735 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 STNSVTGGVYVPPHL---RGG-----GGNNNAADAESQGQGQGQGQGFDS-----------RSG- 81
            |.|.:|...|.....   |||     ||..|.    ::|...|:|:||||           |.|
Frog    35 SNNDITNQNYQSERSFGNRGGYRSERGGPTNF----NRGSRIGRGRGFDSNRNDQYSDSSERDGY 95

  Fly    82 NPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGD-YGYGSGGGGRRGGGGRFEDNYNGGE--F 143
            |..::|:.|.:.||              ||..::|. .|:|..||.|         |.||.:  |
Frog    96 NANEDTQKPFRGRG--------------GFRNENGQRRGFGDRGGFR---------NENGQQRNF 137

  Fly   144 DSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNEQTAEDGQAQQQQQPRNDRWQEPERP 208
            |.   ||||.||.|....||||||          |.|
Frog   138 DR---GDWNNSGEGEERPRGFGRG----------GFN---------------------------- 161

  Fly   209 AGFDGSEGGQSAGGNRSYNNRGERGG-GGYNSRWKEGG---GSN-----------VDYTKLGARD 258
             .||...||:        .:||.||| |||..|.:|.|   |.|           |.|..|...|
Frog   162 -NFDSDTGGR--------GHRGGRGGRGGYKGRNEEVGVESGKNQEEGTEKEVKKVIYVPLPPSD 217

  Fly   259 ERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQK 323
            .  |.::|....:|||||||::|.|:.||::|||.|.:|::....|.:..||..|.|.|.|||||
Frog   218 S--EDDIFRHYQSGINFDKYDEILVDVTGKDVPPAILTFEEANFCETLSRNVTKAGYVKLTPVQK 280

  Fly   324 HAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSRRKQYPLGLVLAPTR 388
            |:||||:.|||||||||||||||||||:|||:.|...|      .|.......|.|..:::||||
Frog   281 HSIPIILAGRDLMACAQTGSGKTAAFLLPILSHMMNEG------ITASQFLPLQEPQAIIIAPTR 339

  Fly   389 ELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGKVGLENI 453
            ||..||:.:|:||:|.:.:||.|:|||.:....||:::|||:::.||||||.|:|.|.|:||..:
Frog   340 ELINQIYLDARKFSYGTCVRPVVVYGGIHPVHAMRDVERGCNILCATPGRLMDIIGREKIGLSKL 404

  Fly   454 RFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFL-SNYIFLAV 517
            ::||||||||||||||.|.:..::....||...:|||||||||:|.:||.|||.|| |:::|:.|
Frog   405 KYLVLDEADRMLDMGFAPVMENLIGSPGMPAKEERQTLMFSATYPAEIQRLASKFLKSDHLFVVV 469

  Fly   518 GRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEEFLYQC 582
            |.||....::.||||.:.|..||..|:::|.|       :.:..|:|||.|||.||.:..:|.|.
Frog   470 GLVGGACSDVEQTILEIQEYRKRDKLVEILQS-------SGNERTMIFVNTKKKADVIAGYLCQE 527

  Fly   583 NHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRI 647
            :.|.|||||||.|.:||||:|.||||.||::|.||||||||||.:|:||||:|:|.:::||||||
Frog   528 HFPTTSIHGDREQCQREEAIRDFRSGKCPVIVCTAVAARGLDIENVQHVINYDVPKEIDEYVHRI 592

  Fly   648 GRTGRMGNLGVATSFFN-EKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHG------GAKRAG 705
            |||||.||:|.|||||| .::..:...|:::|.:..||:|:::|:::.. |||      .|...|
Frog   593 GRTGRCGNVGKATSFFNVNEDHVVARPLVKILTDAHQEVPAWLEEIAFG-GHGALNSLYAADSMG 656

  Fly   706 RGGGGRYGGGFGSRDYRQSS 725
            ...|.:|.....|....::|
Frog   657 GEAGEKYVSAPSSAQEEEAS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	115/219 (53%)
		DEXDc	315..529	CDD:214692	114/214 (53%)
		Helicase_C	538..654	CDD:278689	65/115 (57%)
ddx4	XP_012818309.1	Cyano_gly_rpt	<113..162	CDD:275087	26/99 (26%)
		DEADc_DDX4	210..473	CDD:350810	137/270 (51%)
		SF2_C_DEAD	479..608	CDD:350174	76/135 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920