Protein Alignment bel and DDX4

DIOPT Version :10

• Sequence 1: NP_001262379.1
• Gene: bel / 45826
• FlyBaseID: FBgn0263231
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_077726.1
• Gene: DDX4 / 54514
• HGNCID: 18700
• Length: 724
• Species: Homo sapiens
• Alignment Length: 775
• Identity: 315/775 - (40%)
• Similarity: 423/775 - (54%)
• Gaps: 120/775 - (15%)

  Fly    24 GSADYSGPITSKTSTNSVTGGVYVP----PHLRGGGGNN-NAADAESQGQGQG------------ 71
            |..|:...|....|:       |||    ....|..|:| |...|.|.....|
Human     2 GDEDWEAEINPHMSS-------YVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGF 59

  Fly    72 -QGQGFDSRSGNPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGDYGYGSGGGGRRGGGGRFE 135
             .|:.|.:|......: ||...:.||.|.   |...|.|||:  :..:..|...|..|......|
Human    60 ASGRNFGNRDAGECNK-RDNTSTMGGFGV---GKSFGNRGFS--NSRFEDGDSSGFWRESSNDCE 118

  Fly   136 DNYNGGEFDSRRGG--DWNRSGGGGGGGRGFGRGPSYRG--GGGGSGSNLNEQTAEDGQAQQQQQ 196
            ||.......|:|||  |.|.|...|...|| ||| |:||  ||.|.||
Human   119 DNPTRNRGFSKRGGYRDGNNSEASGPYRRG-GRG-SFRGCRGGFGLGS----------------- 164

  Fly   197 PRNDRWQEP----ERPAGFDGSEGGQSAG---GNRSYNNRG---ERG-----------GGGYNSR 240
            |.||  .:|    :|..|..||.....:|   |:.|.:..|   |||           |.|.||
Human   165 PNND--LDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNS- 226

  Fly   241 WK---EGG------GSNVDYTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITS 296
            ||   |||      |..|.|......::  |..:|....||||||||:.|.||.:|.:.||.|.:
Human   227 WKSEAEGGESSDTQGPKVTYIPPPPPED--EDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILT 289

  Fly   297 FDDVQLTEIIRNNVALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELG 361
            |::..|.:.:.||:|.|.|.|.|||||::||||:.|||||||||||||||||||:|||..|...|
Human   290 FEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDG 354

  Fly   362 HVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELD 426
                  .|....:..|.|..:::||||||..||:.||:||::.:.:|..|:|||......:|::.
Human   355 ------ITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIV 413

  Fly   427 RGCHLIVATPGRLEDMITRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTL 491
            :||:::.||||||.|:|.:.|:||:.|::||||||||||||||.|::::::....||...|||||
Human   414 QGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTL 478

  Fly   492 MFSATFPKQIQELASDFL-SNYIFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPE 555
            |||||||::||.||::|| |||:|:|||:||....::.||:|.|.:..||..|:::|.:|
Human   479 MFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNI----- 538

  Fly   556 YTKDSLTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAA 620
              .|..|::||||||.||.:..||.|.....|||||||.|:|||:||..||.|.||:||||:|||
Human   539 --GDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAA 601

  Fly   621 RGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFN-EKNRNICSDLLELLIETKQE 684
            |||||.:|:|||||||||.::|||||||||||.||.|.|.|||: |.:.::...|:::|.:.:|:
Human   602 RGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQD 666

  Fly   685 IPSFMEDMSSDR---GHGGAKRAGRGGGGRYGGGFGSRDYRQSSG----GGGGGRSGPPP 737
            :|:::|:::...   |..|:.|         |..|.|.|.|:...    .|......|.|
Human   667 VPAWLEEIAFSTYIPGFSGSTR---------GNVFASVDTRKGKSTLNTAGFSSSQAPNP 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc_DDX3	275..522	CDD:350809	130/247 (53%)
		SF2_C_DEAD	527..663	CDD:350174	78/135 (58%)
DDX4	NP_077726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..246		80/278 (29%)
		Interaction with RANBP9. /evidence=ECO:0000269|PubMed:27622290	228..247		6/18 (33%)
		DEADc_DDX4	257..509	CDD:350810	134/257 (52%)
		Q motif	288..316		11/27 (41%)
		DEAD box. /evidence=ECO:0000250|UniProtKB:Q61496	446..449		2/2 (100%)
		SF2_C_DEAD	515..644	CDD:350174	78/135 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..724		3/14 (21%)