DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and DDX4

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_077726.1	Gene:	DDX4 / 54514	HGNCID:	18700	Length:	724	Species:	Homo sapiens

Alignment Length:	775	Identity:	315/775 - (40%)
Similarity:	423/775 - (54%)	Gaps:	120/775 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSADYSGPITSKTSTNSVTGGVYVP----PHLRGGGGNN-NAADAESQGQGQG------------ 71
            |..|:...|....|:       |||    ....|..|:| |...|.|.....|
Human     2 GDEDWEAEINPHMSS-------YVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGF 59

  Fly    72 -QGQGFDSRSGNPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGDYGYGSGGGGRRGGGGRFE 135
             .|:.|.:|......: ||...:.||.|.   |...|.|||:  :..:..|...|..|......|
Human    60 ASGRNFGNRDAGECNK-RDNTSTMGGFGV---GKSFGNRGFS--NSRFEDGDSSGFWRESSNDCE 118

  Fly   136 DNYNGGEFDSRRGG--DWNRSGGGGGGGRGFGRGPSYRG--GGGGSGSNLNEQTAEDGQAQQQQQ 196
            ||.......|:|||  |.|.|...|...|| ||| |:||  ||.|.||
Human   119 DNPTRNRGFSKRGGYRDGNNSEASGPYRRG-GRG-SFRGCRGGFGLGS----------------- 164

  Fly   197 PRNDRWQEP----ERPAGFDGSEGGQSAG---GNRSYNNRG---ERG-----------GGGYNSR 240
            |.||  .:|    :|..|..||.....:|   |:.|.:..|   |||           |.|.||
Human   165 PNND--LDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNS- 226

  Fly   241 WK---EGG------GSNVDYTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITS 296
            ||   |||      |..|.|......::  |..:|....||||||||:.|.||.:|.:.||.|.:
Human   227 WKSEAEGGESSDTQGPKVTYIPPPPPED--EDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILT 289

  Fly   297 FDDVQLTEIIRNNVALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELG 361
            |::..|.:.:.||:|.|.|.|.|||||::||||:.|||||||||||||||||||:|||..|...|
Human   290 FEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDG 354

  Fly   362 HVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELD 426
                  .|....:..|.|..:::||||||..||:.||:||::.:.:|..|:|||......:|::.
Human   355 ------ITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIV 413

  Fly   427 RGCHLIVATPGRLEDMITRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTL 491
            :||:::.||||||.|:|.:.|:||:.|::||||||||||||||.|::::::....||...|||||
Human   414 QGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTL 478

  Fly   492 MFSATFPKQIQELASDFL-SNYIFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPE 555
            |||||||::||.||::|| |||:|:|||:||....::.||:|.|.:..||..|:::|.:|
Human   479 MFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNI----- 538

  Fly   556 YTKDSLTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAA 620
              .|..|::||||||.||.:..||.|.....|||||||.|:|||:||..||.|.||:||||:|||
Human   539 --GDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAA 601

  Fly   621 RGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFN-EKNRNICSDLLELLIETKQE 684
            |||||.:|:|||||||||.::|||||||||||.||.|.|.|||: |.:.::...|:::|.:.:|:
Human   602 RGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQD 666

  Fly   685 IPSFMEDMSSDR---GHGGAKRAGRGGGGRYGGGFGSRDYRQSSG----GGGGGRSGPPP 737
            :|:::|:::...   |..|:.|         |..|.|.|.|:...    .|......|.|
Human   667 VPAWLEEIAFSTYIPGFSGSTR---------GNVFASVDTRKGKSTLNTAGFSSSQAPNP 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	115/219 (53%)
		DEXDc	315..529	CDD:214692	114/214 (53%)
		Helicase_C	538..654	CDD:278689	69/115 (60%)
DDX4	NP_077726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..246		80/278 (29%)
		Interaction with RANBP9. /evidence=ECO:0000269\|PubMed:27622290	228..247		6/18 (33%)
		SrmB	260..>660	CDD:223587	217/412 (53%)
		Q motif	288..316		11/27 (41%)
		DEAD box. /evidence=ECO:0000250\|UniProtKB:Q61496	446..449		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..724		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720