DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and CG8611

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	169/731 - (23%)
Similarity:	290/731 - (39%)	Gaps:	205/731 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 AESQGQGQGQGQGFD-------SRSGNPRQETRDPQQSRGGGG-----------EYRRGGGGGGR 109
            ||..|:.|.||:...       :|:....::.::|.|....|.           :.||..|||.:
  Fly   143 AERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRREEGGGDQ 207

  Fly   110 GFNRQSGDYGYGSGGGGRRGGGGRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGG 174
            ..:....|....||||..|       ...:....:|::..|...|                  |.
  Fly   208 EASADEEDAKNNSGGGSPR-------VKPSSAVKESKKSSDIEDS------------------GE 247

  Fly   175 GGSGSNLNEQTAEDGQAQ---QQQQPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGG 236
            .|..|..:::..::..||   |:::|:....:.|:.
  Fly   248 SGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKA----------------------------- 283

  Fly   237 YNSRWKEGGGSNVDYTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNV--PPNITSFDD 299
                 :|...:|           |...:..|:      ||:.:...::..||..  |...|.|..
  Fly   284 -----EETSSTN-----------RFRTKKIGL------FDQSDVEALKQLGQRAVKPVKETIFTG 326

  Fly   300 VQLTEI------IRNNVALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMY 358
            .:::.:      ::|...|....:.|.||:..||.::.|:|::..:|||||||.|:.:|::..:
  Fly   327 SKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELL- 390

  Fly   359 ELGHVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFA--YRSRMRPAVLYGGNNTSEQ 421
                    |..:...:||...|.||:.|||||..|.:|..:|..  | :.:.|..|.||.:...:
  Fly   391 --------QKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPY-TWIVPGSLLGGESRKSE 446

  Fly   422 MRELDRGCHLIVATPGRLED-MITRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLN---- 481
            ...|.:|.::::.|||||.| ::......|..::||:||||||:|::|:|..::::||.::
  Fly   447 KARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRA 511

  Fly   482 ------MPPTGQRQTLMFSATFPKQIQELASDFLSNYIFL-----------------------AV 517
                  :|   |.|.::.|||...|:|:||...|.|.:::                       |:
  Fly   512 ECEDKELP---QLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEAL 573

  Fly   518 GRV----GSTSENITQTILWVYEPDKRSYL-------LDLLSSI--RDGPEYTKDSLTLIFVETK 569
            ..|    |...|::| .:|.:.|..:.||:       |..|||:  ::.....|....::|:.|.
  Fly   574 LEVDDGLGEYQEDVT-GVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTT 637

  Fly   570 KGADSLEEFLYQCNHPVT------------------------------SIHGDRTQKEREEALRC 604
            :..:...:.|   |..:|                              .:||..||.||:...|.
  Fly   638 EMVNFHHDML---NEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRG 699

  Fly   605 FRSGDCP--ILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFNEKN 667
            ||  ||.  :|:||.|..||:|:|.:|.|:.:..|....::|||:|||.|.|..|.|..|.....
  Fly   700 FR--DCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSE 762

  Fly   668 RNICSDLLELLIETKQ 683
            ......|.:..|..:|
  Fly   763 AQFVRHLEKKRIRIQQ 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	72/260 (28%)
		DEXDc	315..529	CDD:214692	73/253 (29%)
		Helicase_C	538..654	CDD:278689	41/156 (26%)
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	20/140 (14%)
		P-loop_NTPase	332..548	CDD:304359	71/228 (31%)
		DEXDc	348..554	CDD:214692	69/218 (32%)
		HELICc	601..757	CDD:238034	43/160 (27%)
		DUF4217	805..866	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840