DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and ddx3xb

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	XP_005168845.1	Gene:	ddx3xb / 30116	ZFINID:	ZDB-GENE-980526-150	Length:	721	Species:	Danio rerio

Alignment Length:	831	Identity:	421/831 - (50%)
Similarity:	520/831 - (62%)	Gaps:	144/831 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNAINQNGTGLEQQVAGLDLNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAES 65
            ||:...:|..||:||:|.|||:  |||..|          |||..|:|||||    |..||..::
Zfish     1 MSHVAVENVHGLDQQLAALDLS--SADVQG----------VTGRRYIPPHLR----NKEAAKNDA 49

  Fly    66 Q-GQGQGQGQGFDSRSGNPRQETRDPQQSRGGGGEYR--RGGGGGGRG-----FN----RQSGDY 118
            . |...|:..||.:...:.|....:...|..|.|..|  |||.||.||     :|    .||..:
Zfish    50 PGGWDNGRSNGFVNGYHDGRDNRMNGGSSFAGRGPIRSDRGGRGGFRGKSTASYNPIQPMQSAGF 114

  Fly   119 GYGSGGGGRRGGGGRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNE 183
            ||                       |::..|.||           ..:..:|...||
Zfish   115 GY-----------------------DNKEAGGWN-----------VPKDNAYNSFGG-------- 137

  Fly   184 QTAEDGQAQQQQQPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERG--GGGYNSRWKEGGG 246
                          |:||.:     :.|....|..|.|       |.|||  |||.||||.| ..
Zfish   138 --------------RSDRGK-----SSFFNDRGSSSRG-------RYERGGFGGGGNSRWVE-EC 175

  Fly   247 SNVDYTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVA 311
            .:.|::|....:||||.|||...||||||:||:||||||||.|.|..|..|.|:::.|||..|:.
Zfish   176 RDEDWSKPLPPNERLEHELFSGSNTGINFEKYDDIPVEATGHNGPQPIDRFHDLEMGEIIMGNIN 240

  Fly   312 LARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTR------ 370
            |:||.:||||||||||||.:.||||||||||||||||||:|:|:|:|..|.....|:.:
Zfish   241 LSRYTRPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPVLSQIYTDGPGEALQAAKNSAQEN 305

  Fly   371 -QYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVA 434
             :|.||||||:.||||||||||.||::||:||:|||.:||.|:|||.:..:|:|:|:|||||:||
Zfish   306 GKYGRRKQYPISLVLAPTRELALQIYDEARKFSYRSHVRPCVVYGGADIGQQIRDLERGCHLLVA 370

  Fly   435 TPGRLEDMITRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPK 499
            |||||.||:.|||:||:...:||||||||||||||||||||||||..|||.|.|||:||||||||
Zfish   371 TPGRLVDMMERGKIGLDYCNYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGLRQTMMFSATFPK 435

  Fly   500 QIQELASDFLSNYIFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLL------SSIRDGPEYT- 557
            :||.||.|||.:||||||||||||||||||.::||.|.||||:|||||      |.:::....:
Zfish   436 EIQILARDFLEDYIFLAVGRVGSTSENITQKVVWVEENDKRSFLLDLLNATVIPSEVQESTGESV 500

  Fly   558 ----KDSLTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAV 618
                ||||||:|||||||||:||:|||:..:..|||||||:|::|||||..||||.|||||||||
Zfish   501 EKPGKDSLTLVFVETKKGADALEDFLYREGYACTSIHGDRSQRDREEALHQFRSGRCPILVATAV 565

  Fly   619 AARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQ 683
            |||||||.:||||||||||||:||||||||||||:||||:||||||:||.||..|||::|:|.||
Zfish   566 AARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNDKNGNITKDLLDILVEAKQ 630

  Fly   684 EIPSFMEDMSSDRGHGGAKRAGRGGGGRYGGGFGSRDYRQSSGGGGGGRSGPPPRSGGSGSGGGG 748
            |:||::|.::.:..|   |.:.||...|:.||||:|||||:|..||||..|    .||..:||.|
Zfish   631 EVPSWLESLAYEHQH---KSSSRGRSKRFSGGFGARDYRQNSSSGGGGFGG----RGGRSTGGHG 688

  Fly   749 GSYRSNGNSYGKFGGNSGGGGYYGGGAGGGSYGGSYGGGSASHSSNAPDWW 799
            |   :.|     |||..||.|.:....|   |||:|         :..|||
Zfish   689 G---NRG-----FGGGKGGFGNFYSSDG---YGGNY---------SQVDWW 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	148/225 (66%)
		DEXDc	315..529	CDD:214692	153/220 (70%)
		Helicase_C	538..654	CDD:278689	87/126 (69%)
ddx3xb	XP_005168845.1	DEADc	226..452	CDD:238167	148/225 (66%)
		DEXDc	239..466	CDD:214692	156/226 (69%)
		Helicase_C	502..601	CDD:278689	77/98 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1855
eggNOG	1	0.900	-	-		E2759_KOG0335
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	717	1.000	Inparanoid score	I620
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		otm25777
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2088
SonicParanoid	1	1.000	-	-		X820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870