DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and glh-1

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_491963.1	Gene:	glh-1 / 172414	WormBaseID:	WBGene00001598	Length:	763	Species:	Caenorhabditis elegans

Alignment Length:	809	Identity:	272/809 - (33%)
Similarity:	389/809 - (48%)	Gaps:	170/809 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAESQGQGQGQGQGFDSRSGNPRQ 85
            ::.|.:|......:||...|  ||.:       |||||..:   ..|.|:..|.||.  .||.
Worm     1 MSDGWSDSESAAKAKTGFGS--GGGF-------GGGNNGGS---GFGGGKNGGTGFG--GGNT-- 49

  Fly    86 ETRDPQQSRGGGGEYRRGGGGGGRGF-NRQSGDYGYGSG-------GGGRRG-----------GG 131
                       ||....||..||.|| ..::|..|:|.|       |||..|           ||
Worm    50 -----------GGSGFGGGNTGGSGFGGGKTGGSGFGGGNTCGSGFGGGSTGGSPYGGASSGFGG 103

  Fly   132 GRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGG---------GGSGSNLN----- 182
            ......:..||..|..||    |||.||...|||.|....|||         ||...|.|
Worm   104 STATSGFGSGEKSSAFGG----SGGFGGSATGFGSGGGSFGGGNSGFGEGGHGGGERNNNCFNCQ 164

  Fly   183 ---EQTAEDGQAQQQQQPR----------------NDRWQEPERPAGFDGSEGGQSAGGNRSYNN 228
               .::::..:.:::::||                .:|.....|..||.|..|..:.|||..:..
Worm   165 QPGHRSSDCPEPRKEREPRVCYNCQQPGHTSRECTEERKPREGRTGGFGGGAGFGNNGGNDGFGG 229

  Fly   229 RGERGGG----------------------------------GYNS----------RWKEGGGSNV 249
            .|..|||                                  |:.|          ...||.|...
Worm   230 DGGFGGGEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGVEGEGPKA 294

  Fly   250 DYTKLGARDERLEVELFGVG--NTGINFDKYEDIPVEATGQNVPPNI---TSFDDVQLTEIIRNN 309
            .|..:   ::.:| ::|.:.  :.|:.|:|:.|..|:.|.......|   .:|.:..|||.::.|
Worm   295 TYVPV---EDNME-DVFNMQKISEGLMFNKFFDAEVKLTSSEKTVGIKPCKTFAEANLTETMQKN 355

  Fly   310 VALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSR 374
            ||.|.|.|.||:|::|:|::..|.|:|||||||||||||||:||:.::.:      ..:......
Worm   356 VAHAGYSKTTPIQQYALPLVHQGYDIMACAQTGSGKTAAFLLPIMTRLID------DNNLNTAGE 414

  Fly   375 RKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRL 439
            ...||..::|.||||||.||:.|.:||||::.|....:|||........::::|..:||.|.||:
Worm   415 GGCYPRCIILTPTRELADQIYNEGRKFAYQTMMEIKPVYGGLAVGYNKGQIEKGATIIVGTVGRI 479

  Fly   440 EDMITRGKVGLENIRFLVLDEADRMLD-MGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQE 503
            :.....|.:.|:..||.||||||||:| |||...|..||...:||....|||||||||||..:||
Worm   480 KHFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIETIVNYDSMPRKENRQTLMFSATFPDSVQE 544

  Fly   504 LASDFL-SNYIFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLL-------SSIRDGPEYTKDS 560
            .|..|| .||:.:|:.::|:.::.:.|........:|:..||:||       ::.:....|||.
Worm   545 AARAFLRENYVMIAIDKIGAANKCVLQEFERCERSEKKDKLLELLGIDIDSYTTEKSAEVYTKK- 608

  Fly   561 LTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDI 625
             |::||..:..||:|...|.....|..:|||.|.|:||.||||.||:|..|:|:|||||.|||||
Worm   609 -TMVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDI 672

  Fly   626 PHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFME 690
            ..|.||||:|:|.::::|:||||||||:||.|.||||.:| :.::.|:|:.:|.:.:|.:|.:|:
Worm   673 KGVDHVINYDMPDNIDDYIHRIGRTGRVGNSGRATSFISE-DCSLLSELVGVLADAQQIVPDWMQ 736

  Fly   691 DMSSDRGHGGAKRAGRGGGGRYG-GGFGS 718
                     ||      .||.|| .||||
Worm   737 ---------GA------AGGNYGASGFGS 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	99/220 (45%)
		DEXDc	315..529	CDD:214692	93/215 (43%)
		Helicase_C	538..654	CDD:278689	58/122 (48%)
glh-1	NP_491963.1	zf-CCHC	158..175	CDD:278525	1/16 (6%)
		zf-CCHC	183..200	CDD:278525	1/16 (6%)
		ZnF_C2HC	243..259	CDD:197667	0/15 (0%)
		zf-CCHC	262..279	CDD:278525	2/16 (13%)
		DEADc	343..558	CDD:238167	99/220 (45%)
		DEXDc	359..561	CDD:214692	93/207 (45%)
		Helicase_C	579..701	CDD:278689	58/123 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D595675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930