DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and glh-2

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_491876.1	Gene:	glh-2 / 172361	WormBaseID:	WBGene00001599	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	861	Identity:	279/861 - (32%)
Similarity:	394/861 - (45%)	Gaps:	202/861 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NQNGTGLEQQVAGLDLNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAESQGQGQ 70
            |..|||.     |....||:...||........:...||.       |.|||:|:    ..|.|.
Worm   152 NAGGTGF-----GSGNAGGTGFGSGKAGGTGFGSGKAGGT-------GFGGNSNS----GSGFGS 200

  Fly    71 GQGQGFDSRSGNPRQETRDPQQSRGGGGEYRRGGGG--GGRGFNRQSGDYGYGSGGGGRRGG--- 130
            |...||.  |||       ..:|..|||:....|||  ||.||.......|:||||||:..|
Worm   201 GLTNGFG--SGN-------NHESGFGGGKSGGFGGGNSGGSGFGSGGNSNGFGSGGGGQDRGERN 256

  Fly   131 ---------GGRFED-------------------NYNGGEF-------DSRRG--GDWNRSGGGG 158
                     |.|..|                   .:|..:.       :.|.|  |..:..|||.
Worm   257 NNCFNCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTGGSSGFGGGN 321

  Fly   159 GGGRGF------GRGPSYRG----GGGGSGSNLN-------------------------EQTAED 188
            |||.||      |.|....|    |.||.|.|.|                         .::.:.
Worm   322 GGGTGFDSGLTNGFGSGNNGESGFGSGGFGGNSNGFGSGGGGQDRGERNNNCFNCQQPGHRSNDC 386

  Fly   189 GQAQQQQQPR----------NDR-WQEPERP--------AGFDGSEGGQSAGGN-RSYNNRGERG 233
            .:.:::::||          |.| ..|..:|        :||.|...|...||| ..:.|..|||
Worm   387 PEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTSGFGGGNDGGFGGGNAEGFGNNEERG 451

  Fly   234 --------GGGYNS------------------------------RWKEGGGSNVDYTKLGARDER 260
                    |.|:.|                              ...||.|....|..:   ::.
Worm   452 PMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGAEGEGPKATYVPV---EDN 513

  Fly   261 LEVELFGVG--NTGINFDKYEDIPVEATGQNVPPNI---TSFDDVQLTEIIRNNVALARYDKPTP 320
            :| |:|.:.  :.|:.|:|:.|..|:.|....|..:   .:|.:..|.|.::.|||.|.|.|.||
Worm   514 ME-EVFNMQKISEGLMFNKFFDAEVKITSDKKPVGVKTCKTFSEANLGETMKKNVAHAGYTKTTP 577

  Fly   321 VQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSRRKQYPLGLVLA 385
            :|::.:|:|..|.|:|||||||||||||||:||:.::.:      ............||..::|.
Worm   578 IQQYTLPLIHQGHDIMACAQTGSGKTAAFLLPIMARLID------ENDLNTAGEGGCYPRCIILT 636

  Fly   386 PTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGKVGL 450
            |||||..||:.|.:||||::.|....:|||........::::|..:||.|.||::.....|.:.|
Worm   637 PTRELTDQIYNEGRKFAYQTMMEIRPVYGGLAVGYNKGQIEKGATIIVGTVGRIKHFCEEGTIKL 701

  Fly   451 ENIRFLVLDEADRMLD-MGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFL-SNYI 513
            :..||.||||||||:| |||...|..||...:||....|||||||||||..:||.|.:.| ..||
Worm   702 DKCRFFVLDEADRMIDAMGFGTDIDTIVNYESMPKKENRQTLMFSATFPDSVQEAARNHLKEGYI 766

  Fly   514 FLAVGRVGSTSENITQTILWVYEPDKRSYLLDLL-------SSIRDGPEYTKDSLTLIFVETKKG 571
            .||:.::|:.::.:.|........:|:..||::|       ::.::...|||.  |::||..:..
Worm   767 MLAIDKIGAANKCVLQEFEKCDRSEKKDKLLEILGIDIDSYTTEKNSEVYTKK--TIVFVSQRAM 829

  Fly   572 ADSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDL 636
            ||:|...|.....|..:|||.|.|:||.||||.||:|..|:|:|||||.|||||..|.||||:|:
Worm   830 ADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIKGVDHVINYDM 894

  Fly   637 PSDVEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGA 701
            |.::::|:||||||||:||.|.||||.:| :.|:.|:|:.:|.:..|.:|.:|:..|
Worm   895 PDNIDDYIHRIGRTGRVGNAGRATSFISE-DCNLLSELVRVLSDADQLVPEWMQGAS-------- 950

  Fly   702 KRAGRGGGGRYGGGFG 717
                   ||.:|..||
Worm   951 -------GGNFGASFG 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	96/220 (44%)
		DEXDc	315..529	CDD:214692	92/215 (43%)
		Helicase_C	538..654	CDD:278689	57/122 (47%)
glh-2	NP_491876.1	Keratin_2_tail	69..177	CDD:292827	9/29 (31%)
		zf-CCHC	257..274	CDD:278525	3/16 (19%)
		zf-CCHC	282..299	CDD:278525	1/16 (6%)
		zf-CCHC	371..388	CDD:278525	0/16 (0%)
		PTZ00368	373..508	CDD:173561	23/134 (17%)
		zf-CCHC	396..413	CDD:278525	3/16 (19%)
		PRK01297	459..924	CDD:234938	182/477 (38%)
		zf-CCHC	473..490	CDD:278525	0/16 (0%)
		DEADc	554..763	CDD:238167	94/214 (44%)
		Helicase_C	790..912	CDD:278689	57/123 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920