DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bel and vbh-1

DIOPT Version :9

Sequence 1:	NP_001262379.1	Gene:	bel / 45826	FlyBaseID:	FBgn0263231	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001021793.1	Gene:	vbh-1 / 171888	WormBaseID:	WBGene00006888	Length:	660	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	330/679 - (48%)
Similarity:	410/679 - (60%)	Gaps:	74/679 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 GPSYRGGGGGSGSNLN---EQTAEDGQAQQQQQPRNDRWQEPERPAGFDGSE--GGQ-------S 219
            |..|.|...|:.||..   :|....|..|....|.          |||..|.  .||       .
Worm     5 GVFYNGFANGTPSNNGYAIQQPMVPGMGQMMGAPH----------AGFVPSPYFQGQPQQQQHFK 59

  Fly   220 AGGNRSYNNRGERGGGGYNSRWKEGGGSNVDYTKL----GARDERLEVELFGVGNTGINFDKYED 280
            .|.:.::.|..|.|..|||:....|.|.|.:..:.    ||..|..|..||...::||||||||:
Worm    60 MGYSENFENFDENGSSGYNNFADSGNGFNNNGAESNQWGGAPAEYSESNLFHRTDSGINFDKYEN 124

  Fly   281 IPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQKHAIPIIINGRDLMACAQTGSGK 345
            ||||.:|.:||..|..|::......:..||..:.|.||||||||:||.::..||||:||||||||
Worm   125 IPVEVSGDSVPAAIEHFNEAGFGPAVMENVNRSGYSKPTPVQKHSIPTLLANRDLMSCAQTGSGK 189

  Fly   346 TAAFLVPILNQMYELG--HVPPPQSTRQYSRRKQYPLGLVLAPTRELATQIFEEAKKFAYRSRMR 408
            |||||:||:..:...|  .|.||..|.  .||..||..|||:||||||.||.:||.||:|:|.::
Worm   190 TAAFLLPIIQHILAGGPDMVKPPAFTN--GRRTYYPCALVLSPTRELAIQIHKEATKFSYKSNIQ 252

  Fly   409 PAVLYGG-NNTSEQMRELDRGCHLIVATPGRLEDMITRGKVGLENIRFLVLDEADRMLDMGFEPQ 472
            .|:|||| .|..:|:..|..|.|:::||||||.|:|.:|.:||...|:|||||||||||||||||
Worm   253 TAILYGGRENYRDQVNRLRAGTHILIATPGRLIDIIEQGFIGLAGCRYLVLDEADRMLDMGFEPQ 317

  Fly   473 IRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFL-SNYIFLAVGRVGSTSENITQTILWVYE 536
            ||:||.| .|||...|.|.||||||||:||.||.||| .|||||||||||||||||.|.:|||.|
Worm   318 IRKIVGQ-GMPPKTARTTAMFSATFPKEIQVLAKDFLKDNYIFLAVGRVGSTSENIEQRLLWVNE 381

  Fly   537 PDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEEFLYQCNHPVTSIHGDRTQKEREEA 601
            .:|||.|:::|.:     |:: ::|.|:|||||:||:.|..||.:......|||||..|.|||..
Worm   382 MEKRSNLMEILMN-----EHS-ENLVLVFVETKRGANELAYFLNRQQIRSVSIHGDLKQIERERN 440

  Fly   602 LRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYVHRIGRTGRMGNLGVATSFFNEK 666
            |..||||.|||||||||||||||||:|:||||:|||.|.:|||||||||||.||||:||||||:|
Worm   441 LELFRSGQCPILVATAVAARGLDIPNVRHVINYDLPGDSDEYVHRIGRTGRCGNLGIATSFFNDK 505

  Fly   667 NRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAK------------RAGRGGGGRYGGGFGSR 719
            ||.|..||..|::|:.||:|.::..::::...||.:            |.||||||.:||.|.:.
Worm   506 NRGIGRDLKNLIVESNQEVPEWLHQVAAEGRIGGGQRGGNRRFGATDYRVGRGGGGSFGGNFSNY 570

  Fly   720 DYRQSSGGGGGGRSGPPPRSGGSGSGGGGGSYRSNGNSYGKFGGNS---------GGGGYYGGGA 775
            :   |.|..||..|||    ...||.|||...|...|  |.||.:|         ||||:.|...
Worm   571 N---SGGATGGFGSGP----AYGGSFGGGAPRRPFTN--GGFGAHSSLSSTSNSGGGGGFSGPRR 626

  Fly   776 GGGSYG----GSYGGGSASHSSNAP-DWW 799
            ||.:.|    |..|||..|:...|| |.|
Worm   627 GGFNSGMNRQGGGGGGFYSNPGQAPIDHW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bel	NP_001262379.1	DEADc	297..516	CDD:238167	127/222 (57%)
		DEXDc	315..529	CDD:214692	137/217 (63%)
		Helicase_C	538..654	CDD:278689	69/115 (60%)
vbh-1	NP_001021793.1	PTZ00424	137..528	CDD:185609	236/399 (59%)
		DEADc	141..361	CDD:238167	127/222 (57%)
		HELICc	371..501	CDD:238034	82/135 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I1543
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I645
Isobase	1	0.950	-	0	Normalized mean entropy	S391
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D253442at33208
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		otm14166
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930