DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bel and DDX3X

DIOPT Version :10

Sequence 1:NP_001262379.1 Gene:bel / 45826 FlyBaseID:FBgn0263231 Length:801 Species:Drosophila melanogaster
Sequence 2:NP_001347.3 Gene:DDX3X / 1654 HGNCID:2745 Length:662 Species:Homo sapiens


Alignment Length:810 Identity:413/810 - (50%)
Similarity:492/810 - (60%) Gaps:161/810 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSNAINQNGTGLEQQVAGLDLNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAES 65
            ||:...:|..||:||.||||||.......|...||        |.|:|||||.........|.:|
Human     1 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASK--------GRYIPPHLRNREATKGFYDKDS 57

  Fly    66 QGQGQGQGQ----GFDSRSGNPRQETRDPQQSRGGGGEYR-RGGGGGGRGFNRQSGDYGYGSGGG 125
            .|....:.:    .|.|||           .|||....:. ||.|..||..:|...||. |.|..
Human    58 SGWSSSKDKDAYSSFGSRS-----------DSRGKSSFFSDRGSGSRGRFDDRGRSDYD-GIGSR 110

  Fly   126 GRRGGGGRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNEQTAEDGQ 190
            |.|.|.|:|                                                        
Human   111 GDRSGFGKF-------------------------------------------------------- 119

  Fly   191 AQQQQQPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKEGGGSNVDYTKLG 255
                                                    ||||   ||||.:....: |::|..
Human   120 ----------------------------------------ERGG---NSRWCDKSDED-DWSKPL 140

  Fly   256 ARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTP 320
            ...||||.|||..|||||||:||:||||||||.|.||:|.||.||::.|||..|:.|.||.:|||
Human   141 PPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTP 205

  Fly   321 VQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTR------QYSRRKQYP 379
            |||||||||...||||||||||||||||||:|||:|:|..|   |.::.|      :|.||||||
Human   206 VQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDG---PGEALRAMKENGRYGRRKQYP 267

  Fly   380 LGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMIT 444
            :.||||||||||.||:|||:||:||||:||.|:|||.:..:|:|:|:|||||:|||||||.||:.
Human   268 ISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMME 332

  Fly   445 RGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFL 509
            |||:||:..::||||||||||||||||||||||||..|||.|.|.|:||||||||:||.||.|||
Human   333 RGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFL 397

  Fly   510 SNYIFLAVGRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADS 574
            ..||||||||||||||||||.::||.|.||||:|||||::.      .||||||:||||||||||
Human   398 DEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNAT------GKDSLTLVFVETKKGADS 456

  Fly   575 LEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSD 639
            ||:|||...:..|||||||:|::|||||..||||..|||||||||||||||.:||||||||||||
Human   457 LEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSD 521

  Fly   640 VEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAKRA 704
            :||||||||||||:||||:|||||||:|.||..|||:||:|.|||:||::|:|:.:..:.|:.| 
Human   522 IEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSR- 585

  Fly   705 GRGGGGRYGGGFGSRDYRQSSGGGGGGRSGPPPRSGGSGSGGGGGSYRSNGNSYGKFGGNSGGGG 769
            ||....|:.||||:||||||||......|.  .|:..|.|||||     :|:|.|     .||||
Human   586 GRSKSSRFSGGFGARDYRQSSGASSSSFSS--SRASSSRSGGGG-----HGSSRG-----FGGGG 638

  Fly   770 YYGGGAGGGSYGGSYGGGSASHSSNAPDWW 799
             |||......|||:|       :|...|||
Human   639 -YGGFYNSDGYGGNY-------NSQGVDWW 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
belNP_001262379.1 DEADc_DDX3 275..522 CDD:350809 174/252 (69%)
SF2_C_DEAD 527..663 CDD:350174 99/135 (73%)
DDX3XNP_001347.3 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090 2..139 56/256 (22%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075 12..21 6/8 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 49/244 (20%)
Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941 38..44 4/5 (80%)
Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487 81..90 1/8 (13%)
Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975 88..123 17/131 (13%)
Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110 100..662 374/692 (54%)
Interaction with IKBKE 100..110 4/10 (40%)
Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941 139..172 22/32 (69%)
DEADc_DDX3 160..410 CDD:350809 174/252 (69%)
Q motif 180..208 15/27 (56%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication 250..259 1/8 (13%)
DEAD box 347..350 2/2 (100%)
Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544 409..662 168/279 (60%)
SF2_C_DEAD 415..545 CDD:350174 99/135 (73%)
Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238 536..661 70/146 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634 18/44 (41%)

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