DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bel and Ddx3x

DIOPT Version :9

Sequence 1:NP_001262379.1 Gene:bel / 45826 FlyBaseID:FBgn0263231 Length:801 Species:Drosophila melanogaster
Sequence 2:NP_034158.1 Gene:Ddx3x / 13205 MGIID:103064 Length:662 Species:Mus musculus


Alignment Length:806 Identity:418/806 - (51%)
Similarity:498/806 - (61%) Gaps:153/806 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSNAINQNGTGLEQQVAGLDLNGGSADYSGPITSKTSTNSVTGGVYVPPHLRGGGGNNNAADAES 65
            ||:...:|..||:||.||||||.......|...||        |.|:|||||.........|.:|
Mouse     1 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASK--------GRYIPPHLRNREATKGFYDKDS 57

  Fly    66 QGQGQGQGQGFDSRSGNPRQETRDPQQSRGGGGEYRRGGGGGGRGFNRQSGDYGYGSGGGGRRGG 130
                          ||....:.:|...|.|..|:        .||.:...||          ||.
Mouse    58 --------------SGWSSSKDKDAYSSFGSRGD--------SRGKSSFFGD----------RGS 90

  Fly   131 GGRFEDNYNGGEFDSRRGGDWNRSGGGGGGGRGFGRGPSYRGGGGGSGSNLNEQTAEDGQAQQQQ 195
            |.|       |.||.|..||::     |.||||                                
Mouse    91 GSR-------GRFDDRGRGDYD-----GIGGRG-------------------------------- 111

  Fly   196 QPRNDRWQEPERPAGFDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKEGGGSNVDYTKLGARDER 260
                ||       :||                .:.||||   ||||.:....: |::|.....||
Mouse   112 ----DR-------SGF----------------GKFERGG---NSRWCDKSDED-DWSKPLPPSER 145

  Fly   261 LEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALARYDKPTPVQKHA 325
            ||.|||..|||||||:||:||||||||.|.||:|.||.||::.|||..|:.|.||.:||||||||
Mouse   146 LEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHA 210

  Fly   326 IPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTR------QYSRRKQYPLGLVL 384
            ||||...||||||||||||||||||:|||:|:|..|   |.::.|      :|.||||||:.|||
Mouse   211 IPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADG---PGEALRAMKENGRYGRRKQYPISLVL 272

  Fly   385 APTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMITRGKVG 449
            |||||||.||:|||:||:||||:||.|:|||....:|:|:|:|||||:|||||||.||:.|||:|
Mouse   273 APTRELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMERGKIG 337

  Fly   450 LENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDFLSNYIF 514
            |:..::||||||||||||||||||||||||..|||.|.|.|:||||||||:||.||.|||..|||
Mouse   338 LDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIF 402

  Fly   515 LAVGRVGSTSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGADSLEEFL 579
            |||||||||||||||.::||.|.||||:|||||::.      .||||||:||||||||||||:||
Mouse   403 LAVGRVGSTSENITQKVVWVEEIDKRSFLLDLLNAT------GKDSLTLVFVETKKGADSLEDFL 461

  Fly   580 YQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLPSDVEEYV 644
            |...:..|||||||:|::|||||..||||..|||||||||||||||.:||||||||||||:||||
Mouse   462 YHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYV 526

  Fly   645 HRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAKRAGRGGG 709
            ||||||||:||||:|||||||:|.||..|||:||:|.|||:||::|:|:.:..:.|:.| ||...
Mouse   527 HRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSR-GRSKS 590

  Fly   710 GRYGGGFGSRDYRQSSGGGGGGRSGPPPRSGGSGSGGGGGSYRSNGNSYGKFGGNSG-GGGYYGG 773
            .|:.||||:||||||||......|.  .|:..|.|||||            .||:.| |||.|||
Mouse   591 SRFSGGFGARDYRQSSGASSSSFSS--SRASSSRSGGGG------------HGGSRGFGGGGYGG 641

  Fly   774 GAGGGSYGGSYGGGSASHSSNAPDWW 799
            ......|||:|       :|...|||
Mouse   642 FYNSDGYGGNY-------NSQGVDWW 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
belNP_001262379.1 DEADc 297..516 CDD:238167 152/224 (68%)
DEXDc 315..529 CDD:214692 156/219 (71%)
Helicase_C 538..654 CDD:278689 86/115 (75%)
Ddx3xNP_034158.1 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571 2..139 62/251 (25%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571 12..21 6/8 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 55/239 (23%)
Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571 38..44 4/5 (80%)
PTZ00110 57..580 CDD:240273 352/638 (55%)
eIF-4B 80..>172 CDD:283846 54/176 (31%)
Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571 100..662 375/660 (57%)
Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571 100..110 4/14 (29%)
Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571 139..172 22/32 (69%)
Q motif 180..208 15/27 (56%)
DEADc 182..404 CDD:238167 152/224 (68%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571 250..259 1/8 (13%)
DEAD box 347..350 2/2 (100%)
Helicase_C 426..536 CDD:278689 86/115 (75%)
Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571 536..661 69/147 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..633 17/45 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 265 1.000 Domainoid score I1883
eggNOG 1 0.900 - - E2759_KOG0335
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3425
Inparanoid 1 1.050 693 1.000 Inparanoid score I682
Isobase 1 0.950 - 0 Normalized mean entropy S391
OMA 1 1.010 - - QHG53695
OrthoDB 1 1.010 - - D253442at33208
OrthoFinder 1 1.000 - - FOG0000634
OrthoInspector 1 1.000 - - otm42597
orthoMCL 1 0.900 - - OOG6_100461
Panther 1 1.100 - - LDO PTHR47958
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2088
SonicParanoid 1 1.000 - - X820
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.860

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