DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and GRAP2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_004801.1 Gene:GRAP2 / 9402 HGNCID:4563 Length:330 Species:Homo sapiens


Alignment Length:212 Identity:66/212 - (31%)
Similarity:100/212 - (47%) Gaps:48/212 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            ||.:||.|.||::||...|:.::|||..:  ||.:|...| ..|:||.|::    .::...|:|.
Human     4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGS-QEGYVPKNFI----DIQFPKWFHE 61

  Fly   276 PISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTL 340
            .:||:.||.||.....|.|::|.|:||||..|||:|:|..|.|:::..|..|..|:..| ||.:|
Human    62 GLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE-KFPSL 125

  Fly   341 AELVHHHSV-------------------PHEGHGLIT-----PLLYPA------PKQNK-----P 370
            .:||.::..                   .|.|:.|..     |.|..|      |..|:     |
Human   126 NKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHP 190

  Fly   371 TVFPL-----SPEPDEW 382
            ...||     .|:|.::
Human   191 PTLPLQQHQHQPQPPQY 207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 21/51 (41%)
SH2_ABL 268..363 CDD:198189 37/118 (31%)
PTKc_Abl 382..644 CDD:270645 0/1 (0%)
FABD 1584..1723 CDD:197885
GRAP2NP_004801.1 SH3_GRAP2_N 2..53 CDD:212880 21/55 (38%)
SH2_Grb2_like 54..147 CDD:199828 32/93 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..244 13/65 (20%)
SH3_GRAP2_C 275..327 CDD:212883
Blue background indicates that the domain is not in the aligned region.

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