DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and RIPK2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_003812.1 Gene:RIPK2 / 8767 HGNCID:10020 Length:540 Species:Homo sapiens


Alignment Length:603 Identity:134/603 - (22%)
Similarity:225/603 - (37%) Gaps:154/603 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 HKLGGGQY------GEVYEAVWKRYGNTVAVKTLKEDTMAL----KDFLEEAAIMKEMKHPNLVQ 447
            |||...:|      |.|..|....:...||||.|...|..|    ||.|.||.|:.:.:...::.
Human    16 HKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 80

  Fly   448 LIGVCTREPPFY-IITEFMSHGNLLDFLRSAGRETLDAVALLY-MATQIASGMSYLESRN--YIH 508
            ::|:| .||.|. |:||:|.:|:|.:.|.........|..|.: :..:||.|::||.:..  .:|
Human    81 ILGIC-NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLH 144

  Fly   509 RDLAARNCLVGDNKLVKVADFGLA--RLMRDDTYTAHAGAKFPIKWTAPEG--LAY--------- 560
            .||..:|.|:.:...||:|||||:  |:|   :.:....:|     :||||  :.|         
Human   145 HDLKTQNILLDNEFHVKIADFGLSKWRMM---SLSQSRSSK-----SAPEGGTIIYMPPENYEPG 201

  Fly   561 --NKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD---VYHKLDKGYR-----MERPPGCP--P 613
              ::.|.|.|::::.|:.||:.:   ...|..|:|:   :.:.:.:|:|     ...|...|  .
Human   202 QKSRASIKHDIYSYAVITWEVLS---RKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRA 263

  Fly   614 EVYDLMRQCWQWDATDRPTFKSIHHALE---HMFQESSITEAVEKQLNANATSASSSAPSTSGVA 675
            .:..|:...|..:..:||:|......||   ..|:|.:..|||.:.......|.||         
Human   264 RMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSS--------- 319

  Fly   676 TGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSE-TGS 739
                     |...|   ......|||       .:|        .:|....:...|:.:.| :||
Human   320 ---------AIHLC---DKKKMELSL-------NIP--------VNHGPQEESCGSSQLHENSGS 357

  Fly   740 TSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLST 804
            ..|                      .:..|||.....|...::|            |.|:.    
Human   358 PET----------------------SRSLPAPQDNDFLSRKAQD------------CYFMK---- 384

  Fly   805 NGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQ 869
              :|.....:.:..|:|.:.:.....|.|....:.......:....:::.|...||..   |.|:
Human   385 --LHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWI---QSKR 444

  Fly   870 QQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSE---TDPAAD-------PDTDATGDSLEQ 924
            :....:.:.:|.:...|.|   |:||   |..:.|.|   |.|...       ..||..|    :
Human   445 EDIVNQMTEACLNQSLDAL---LSRD---LIMKEDYELVSTKPTRTSKVRQLLDTTDIQG----E 499

  Fly   925 SLSQVIAAPVTNKMQHSL 942
            ..::||...:.:..|..|
Human   500 EFAKVIVQKLKDNKQMGL 517

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 79/292 (27%)
FABD 1584..1723 CDD:197885
RIPK2NP_003812.1 STKc_RIP2 20..303 CDD:270928 78/294 (27%)
Helix alphaC. /evidence=ECO:0000269|PubMed:28545134 65..73 3/7 (43%)
Activation segment (AS). /evidence=ECO:0000269|PubMed:28545134 167..193 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 338..369 9/52 (17%)
CARD_RIP2_CARD3 438..524 CDD:176764 21/93 (23%)
Blue background indicates that the domain is not in the aligned region.

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