Protein Alignment Abl and RIPK1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_047275401.1
• Gene: RIPK1 / 8737
• HGNCID: 10019
• Length: 712
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 164/788 - (20%)
• Similarity: 264/788 - (33%)
• Gaps: 247/788 - (31%)

  Fly   337 FNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKP----TVFPLSPEP--DEWEICRTDIMMKHKL 395
            :||.:..|.|...|.......|.|  |..::..|    ..|.:.|:.  :..::..:|.:...:|
Human     2 WNTASGTVAHSCNPSTSEAEGTAL--PGGEKVVPFWAFLSFRMQPDMSLNVIKMKSSDFLESAEL 64

  Fly   396 GGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKD---FLEEAAIMKEMKHPNLVQLIGVCTREPP 457
            ..|.:|:| ...:.|....:.:||:.:....::.   .||||.:|..::|..:|:|:||...|..
Human    65 DSGGFGKV-SLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGK 128

  Fly   458 FYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNK 522
            :.::.|:|..|||:..|::.....|.....:.:  :|..||.||..:..||:||...|.||.::.
Human   129 YSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKDLKPENILVDNDF 191

  Fly   523 LVKVADFGLARLMR---------------DDTYTAHAGAKFPIKWTAPEGL--AYNKFSTKSDVW 570
            .:|:||.|||....               |.|...:.|..:   :.|||.|  ...|.:.||||:
Human   192 HIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY---YMAPEHLNDVNAKPTEKSDVY 253

  Fly   571 AFGVLLWEIATYGMSPY------------------PAIDLTDVYHKLDKGYRMERPPGCPPEVYD 617
            :|.|:||.|.. ...||                  |.:|....|              ||.|:..
Human   254 SFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEY--------------CPREIIS 303

  Fly   618 LMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQL--------NANATSASSSAPSTSGV 674
            ||:.||:.:...||||..|.... ..|..|.:.|:||:.:        |.||......:.....|
Human   304 LMKLCWEANPEARPTFPGIEEKF-RPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCV 367

  Fly   675 ATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGS 739
            |...           :.|:|||..            ||
Human   368 AVPS-----------SRSNSATEQ------------PG--------------------------- 382

  Fly   740 TSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLST 804
                 |..||||.|...:..:......:.|......||.|..:|.
Human   383 -----SLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDE-------------------- 422

  Fly   805 NGIHKLKTANY--FSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQ 867
                    |||  :...:.|..|.| |..:....|.::::::.|..      |.: ||:.::..|
Human   423 --------ANYHLYGSRMDRQTKQQ-PRQNVAYNREEERRRRVSHD------PFA-QQRPYENFQ 471

  Fly   868 KQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAA 932
            ..:......||:.|.                                    |:::.|. |.:.:.
Human   472 NTEGKGTAYSSAASH------------------------------------GNAVHQP-SGLTSQ 499

  Fly   933 PVTNKMQHSLHSGGG-------GGGIGPR------SSQQHSSFKRPT-GTPVMGNRGLETRQSKR 983
            |......:.|:|..|       .|..|||      .|...|....|. .|..:||    |.....
Human   500 PQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGN----TPTMPF 560

  Fly   984 SQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLE 1048
            |.|        ||:.:   .....:.::..|.:||.:.|.:            |....:.|||..
Human   561 SSL--------PPTDE---SIKYTIYNSTGIQIGAYNYMEI------------GGTSSSLLDSTN 602

  Fly  1049 DSSEAAPA 1056
            .:.:..||
Human   603 TNFKEEPA 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	7/25 (28%)
		PTKc_Abl	382..644	CDD:270645	78/299 (26%)
		FABD	1584..1723	CDD:197885
RIPK1	XP_047275401.1	STKc_RIP1	64..331	CDD:270929	78/288 (27%)
		Death_RIP1	624..709	CDD:260048