DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Jak1

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_445918.1 Gene:Jak1 / 84598 RGDID:69056 Length:1153 Species:Rattus norvegicus


Alignment Length:589 Identity:157/589 - (26%)
Similarity:240/589 - (40%) Gaps:130/589 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 LQGSSLGGG-----HSSTTSVFES----AHRWTSKENLLAPGPEEDDPQLFVALYDFQAGG-ENQ 223
            :||..||.|     :|.|...::.    |.....|..|....|...|    ::|..|:|.. ..|
  Rat   583 IQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRD----ISLAFFEAASMMRQ 643

  Fly   224 LS-----------LKKGEQVRILSYNKSGE---WCEAHSDSGNVGW---VPSNYVTPLNSLEKHS 271
            :|           ::..|.:.:..:.:.|.   :....||:....|   |.....:.|:.||...
  Rat   644 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKD 708

  Fly   272 WYHGPI-SRNAAEYLLSSGIN---GSFLVRESESSPG-QRSISLRYEGRVYHYRISEDP------ 325
            ..||.: ::|.  .|...||:   |.|:   ..|.|| ..|:..|.|      .|...|      
  Rat   709 LVHGNVCTKNL--LLAREGIDSDIGPFI---KLSDPGIPVSVLTRQE------CIERIPWIAPEC 762

  Fly   326 --DGKVFVTQEAKFN---TLAELVHHHSVPHEGHGLI-------------TPL------------ 360
              |.|.......|::   ||.|:.::..:|.:...||             ||.            
  Rat   763 VEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCM 827

  Fly   361 ----------------LYPAPKQNKPTVFPLSP----EPDEWEICRTDIMMKHKLGGGQYGEV-- 403
                            :....:||...|....|    :|..:|  :..:.....||.|.:|:|  
  Rat   828 NYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFE--KRFLKRIRDLGEGHFGKVEL 890

  Fly   404 --YEAVWKRYGNTVAVKTLKEDTMA--LKDFLEEAAIMKEMKHPNLVQLIGVCTRE--PPFYIIT 462
              |:......|..||||:||.::..  :.|..:|..|::.:.|.|:|:..|:|..:  ....:|.
  Rat   891 CRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIM 955

  Fly   463 EFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVA 527
            ||:..|:|.::| ...:..::....|..|.||..||.||.||.|:||||||||.||.....||:.
  Rat   956 EFLPSGSLKEYL-PKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG 1019

  Fly   528 DFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAI 590
            ||||.:.:..|.  ||.......|:.|.|||.|...||...||||:|||.|.|:.||..|.:..:
  Rat  1020 DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPM 1084

  Fly   591 DL--------------TDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641
            .|              |.:.:.|.:|.|:..||.||.|||.|||:||::..::|.||:::....|
  Rat  1085 ALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFE 1149

  Fly   642 HMFQ 645
            .:.:
  Rat  1150 ALLK 1153

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 11/71 (15%)
SH2_ABL 268..363 CDD:198189 28/151 (19%)
PTKc_Abl 382..644 CDD:270645 99/285 (35%)
FABD 1584..1723 CDD:197885
Jak1NP_445918.1 FERM_F1 <52..129 CDD:465733
FERM_F2 147..277 CDD:436450
FERM_C_JAK1 282..426 CDD:275412
SH2_Jak1 426..526 CDD:198241
PTK_Jak1_rpt1 582..845 CDD:270662 53/276 (19%)
PTKc_Jak1_rpt2 869..1152 CDD:173644 99/285 (35%)
Blue background indicates that the domain is not in the aligned region.

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