Protein Alignment Abl and Src

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_114183.1
• Gene: Src / 83805
• RGDID: 620795
• Length: 542
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 222/528 - (42%)
• Similarity: 312/528 - (59%)
• Gaps: 57/528 - (10%)

  Fly   139 PHIPA------GSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENL 197
            |..||      |..||.:...|||               ..|.||.:|:.:|       ||.:.
  Rat    37 PSKPASADGHRGPNAAFVPPAAAE---------------PKLFGGFNSSDTV-------TSPQR- 78

  Fly   198 LAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYN-----KSGEWCEAHS-DSGNVGWV 256
              .||.......||||||:::..|..||.||||:::|::..     :.|:|..||| .:|..|::
  Rat    79 --AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYI 141

  Fly   257 PSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYEG- 314
            |||||.|.:|::...||.|.|:|..:|.||.:..|  |:|||||||::.|...:|:    ..:|
  Rat   142 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 206

  Fly   315 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEG--HGLITPLLYPAPKQNKPTVFPLSP 377
            .|.||:|.:...|..::|...:||:|.:||.::|...:|  |.|.|  :.|.   :||....|:
  Rat   207 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPT---SKPQTQGLA- 265

  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT-VAVKTLKEDTMALKDFLEEAAIMKEMK 441
             .|.|||.|..:.::.|||.|.:|||:...|.  |.| ||:||||..||:.:.||:||.:||:::
  Rat   266 -KDAWEIPRESLRLEVKLGQGCFGEVWMGTWN--GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 327

  Fly   442 HPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNY 506
            |..||||..|.:.| |.||:||:|:.|:|||||:....:.|....|:.|:.||||||:|:|..||
  Rat   328 HEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNY 391

  Fly   507 IHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWA 571
            :||||.|.|.|||:|.:.||||||||||:.|:.|||..||||||||||||...|.:|:.|||||:
  Rat   392 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 456

  Fly   572 FGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSI 636
            ||:||.|:.|.|..|||.:...:|..::::||||..||.||..::|||.|||:.:..:||||:.:
  Rat   457 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 521

  Fly   637 HHALEHMF 644
            ...||..|
  Rat   522 QAFLEDYF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	26/59 (44%)
		SH2_ABL	268..363	CDD:198189	36/103 (35%)
		PTKc_Abl	382..644	CDD:270645	134/262 (51%)
		FABD	1584..1723	CDD:197885
Src	NP_114183.1	PTKc_Src	266..542	CDD:270656	136/267 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		3/11 (27%)
		SH3_Src	88..149	CDD:212941	26/60 (43%)
		SH2_Src_Src	153..253	CDD:198228	36/101 (36%)