DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and itk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio

Alignment Length:	472	Identity:	182/472 - (38%)
Similarity:	277/472 - (58%)	Gaps:	32/472 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 LAPGPE------EDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWV 256
            |.|.|:      |.:.::.|||.:|.......|.|:|.|:..|:..::...|.....| ||||.|
Zfish   153 LPPTPDPSRRSSEPEERIVVALRNFIPKEHTDLPLQKDEEYFIVDCSEPNWWTVKDKD-GNVGSV 216

  Fly   257 PSNYVTP--LNSLEKHSWYHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISL--RYEG-- 314
            |..|||.  .|::||..||:..|:|..|| .|:....:|.|:||.|:.: |..::|:  |..|
Zfish   217 PCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLMQENKDGGFMVRNSKHA-GVYTVSIFTRVSGSN 280

  Fly   315 -----RVYHYRISEDPDGK---VFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQ--NK 369
                 :|.||:|....:|:   .::.::..|.|:.||:.:|.  |...||||.|.:...:.  |.
Zfish   281 GEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQ--HNPAGLITRLRHCVSRNVPNS 343

  Fly   370 PTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEA 434
            ..:..||  .|:|||...::.:..:||.||:|.|::..|:  ...|||||::|..|:.::|.|||
Zfish   344 ARIKELS--SDKWEIHPDEVKLSVELGSGQFGLVWKGSWQ--DREVAVKTVREGFMSEEEFKEEA 404

  Fly   435 AIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMS 499
            .:|.::.|..||||.||.|:..|.|::.|||.:|.|.:||| |.:..|...|||.|...::.||:
Zfish   405 QVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLR-AKKGKLSQKALLEMCLDVSEGMA 468

  Fly   500 YLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFS 564
            ||||.|:||||||||||||.:|.:||:||||:.|.:.||.||:..|:|||::|::||.:.:.|:|
Zfish   469 YLESSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYS 533

  Fly   565 TKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATD 629
            :|||||:|||.:||:.:.|.:||.....::|...|:.|:|:.:|..||..||:||:..|:....|
Zfish   534 SKSDVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEKPED 598

  Fly   630 RPTFKSIHHALEHMFQE 646
            ||:|..:.|.|..:.||
Zfish   599 RPSFALLLHELACLDQE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	19/53 (36%)
		SH2_ABL	268..363	CDD:198189	34/107 (32%)
		PTKc_Abl	382..644	CDD:270645	117/261 (45%)
		Pkinase_Tyr	389..640	CDD:285015	113/250 (45%)
		FABD	1584..1723	CDD:197885
itk	NP_571179.1	PH	5..110	CDD:278594
		PH_Btk	7..147	CDD:269944
		SH3_Tec_like	170..223	CDD:212702	19/53 (36%)
		SH2_Tec_family	227..338	CDD:198188	35/113 (31%)
		PKc_like	356..610	CDD:304357	114/256 (45%)
		Pkinase_Tyr	361..609	CDD:285015	113/250 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920