DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and MAP3K12

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001180440.1 Gene:MAP3K12 / 7786 HGNCID:6851 Length:892 Species:Homo sapiens


Alignment Length:943 Identity:207/943 - (21%)
Similarity:337/943 - (35%) Gaps:298/943 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAI--MKEM 440
            :.|.||:...:|:....:|.|..|.|:  :.:.:|..||||.:::        |:|..|  ::::
Human   147 QEDLWEVPFEEILDLQWVGSGAQGAVF--LGRFHGEEVAVKKVRD--------LKETDIKHLRKL 201

  Fly   441 KHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRN 505
            ||||::...||||:.|.:.|:.||.:.|.|.:.|| |||....:: |:..:..||.||:||....
Human   202 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR-AGRPVTPSL-LVDWSMGIAGGMNYLHLHK 264

  Fly   506 YIHRDLAARNCLVGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDV 569
            .|||||.:.|.|:..:.:||::|||.::.:.| .|..:.||.   :.|.|||.:.....|.|.|:
Human   265 IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDI 326

  Fly   570 WAFGVLLWEIATYGMSPYPAIDLTDVYHKL-DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTF 633
            |:|||:|||:.| |..||..:|.:.:...: .....:..|..||.....|:||||.....:||:|
Human   327 WSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 390

  Fly   634 KSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATAS 698
            :.|   |.|:                                                 ..|:|.
Human   391 RQI---LLHL-------------------------------------------------DIASAD 403

  Fly   699 LSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNK 763
            :..|||                               ||        .|.||.:           
Human   404 VLSTPQ-------------------------------ET--------YFKSQAE----------- 418

  Fly   764 QGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNG--IHKLKTANYFSQTLSRNFKT 826
                                  :|||    .:.:| :.:.:.|  :|:|:      :.|....:.
Human   419 ----------------------WREE----VKLHF-EKIKSEGTCLHRLE------EELVMRRRE 450

  Fly   827 QIPTHHTHQIRTQQQQQ-QQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFR 890
            ::  .|...||...::: :::.....::..|.:|.:..:::..:::.::::  .|...|.....|
Human   451 EL--RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER--RCPGLLKPHPSR 511

  Fly   891 GLARDINSLTQRYDSETDP------AADPD---TDATGDSLEQSLSQVIAAPVTNKMQHSLHSGG 946
            ||... |::.:.......|      :..||   |::....|:.:||.|               |.
Human   512 GLLHG-NTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGV---------------GL 560

  Fly   947 GGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHH--------G 1003
            .|...||.|             |....|| :||..|.|...|....||..:..|.|        |
Human   561 PGCPKGPPS-------------PGRSRRG-KTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPG 611

  Fly  1004 NNGVVTSA------------HPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPA 1056
            ..|...||            |.:.:..:...:...:....|:..:||..||     .|.....||
Human   612 GLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGA-----GDPGSPPPA 671

  Fly  1057 LPATAPSLPPANGHATP--PAARLNPKASPIPPQQMI------------RSNSSGGVTMQNNAA- 1106
            ...|.||...|.|..:|  |.........|:.|.:.:            |..|..|......|| 
Human   672 RGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAAL 736

  Fly  1107 ---ASLNKLQRHRTTTE----------------------GTMMTFSSFRAGGSSSSPKRSASGVA 1146
               |::.:.|:...::|                      ....:.|:|    ||.:|.....|.|
Human   737 LYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTF----SSENPSDGEEGTA 797

  Fly  1147 SGVQPA------LANLEFPPP-------------PLDLPPPPEEFEGGPPPPPPAPESAVQAIQQ 1192
            |...|:      ..|.:..|.             ||| |||.|...|..|...|.|.      |:
Human   798 SEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLD-PPPSEVIPGPEPSSLPIPH------QE 855

  Fly  1193 HLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAP 1225
            .|..:.|.|...|:.:.|..::|  |.|..:.|
Human   856 LLRERGPPNSEDSDCDSTELDNS--NSVDALRP 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 90/265 (34%)
FABD 1584..1723 CDD:197885
MAP3K12NP_001180440.1 STKc_MAP3K12_13 164..400 CDD:270961 87/303 (29%)
Blue background indicates that the domain is not in the aligned region.

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