Protein Alignment Abl and ZAP70

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 157/488 - (32%)
• Similarity: 237/488 - (48%)
• Gaps: 92/488 - (18%)

  Fly   268 EKHSWYHGPISRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVF 330
            |:..|||..::|..||..|.||  .:|.||:|..:.. |..::||.|...||||.||:|..||..
Human   247 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGKYC 310

  Fly   331 VTQEAKFNTLAELVHHHSVPHEG-----------------HGLITPLL----------------- 361
            :.:..||:||.:||.:..:..:|                 .|...|.|
Human   311 IPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTL 375

  Fly   362 -----YPAPKQ----NKPTVFPL------SPEPDEWEICRTDIMMKH--------KLGGGQYGEV 403
                 .|.|.:    :||...|:      ||..|..|:....:.:|.        :||.|.:|.|
Human   376 NSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSV 440

  Fly   404 YEAVW--KRYGNTVAVKTLKEDT--MALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEF 464
            .:.|:  ::....||:|.||:.|  ...::.:.||.||.::.:|.:|:|||||..| ...::.|.
Human   441 RQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEM 504

  Fly   465 MSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADF 529
            ...|.|..|| ...||.:....:..:..|::.||.|||.:|::||||||||.|:.:....|::||
Human   505 AGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 568

  Fly   530 GLAR-LMRDDT-YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDL 592
            ||:: |..||: |||.:..|:|:||.|||.:.:.|||::||||::||.:||..:||..||..:..
Human   569 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 633

  Fly   593 TDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQL 657
            .:|...:::|.|||.||.||||:|.||..||.:...|||.|.:                 ||:::
Human   634 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLT-----------------VEQRM 681

  Fly   658 NANATSASSSAPSTSGVATGGGATTTTAASGCA 690
            .|...|.:|......|       :|..|.:.||
Human   682 RACYYSLASKVEGPPG-------STQKAEAACA 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	37/135 (27%)
		PTKc_Abl	382..644	CDD:270645	102/275 (37%)
		FABD	1584..1723	CDD:197885
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191
		SH2_C-SH2_Zap70	240..343	CDD:198265	34/96 (35%)
		PTKc_Zap-70	421..689	CDD:270686	105/286 (37%)