DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and YES1

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_005424.1 Gene:YES1 / 7525 HGNCID:12841 Length:543 Species:Homo sapiens


Alignment Length:490 Identity:219/490 - (44%)
Similarity:296/490 - (60%) Gaps:36/490 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 GLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQV 232
            |..|.:..||.||:.||..|::          |........:||||||::|.....||.||||:.
Human    64 GSSGVTPFGGASSSFSVVPSSY----------PAGLTGGVTIFVALYDYEARTTEDLSFKKGERF 118

  Fly   233 RILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSF 294
            :|:: |..|:|.||.| .:|..|::|||||.|.:|::...||.|.:.|..||.||.:..|  |.|
Human   119 QIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIF 182

  Fly   295 LVRESESSPGQRSISLR----YEG-RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEG- 353
            ||||||::.|..|:|:|    ..| .|.||:|.:..:|..::|..|:|:||.:||.|::...:| 
Human   183 LVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGL 247

  Fly   354 -HGLITPLLYPAPKQNKPTVFPLSP--EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT- 414
             |.|.|..         |||.|.:.  ..|.|||.|..:.::.|||.|.:|||:...|.  |.| 
Human   248 CHKLTTVC---------PTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN--GTTK 301

  Fly   415 VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGR 479
            ||:||||..||..:.||:||.|||:::|..||.|..|.:.| |.||:|||||.|:|||||:....
Human   302 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDG 365

  Fly   480 ETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHA 544
            :.|....|:.||.|||.||:|:|..|||||||.|.|.|||:|.:.|:||||||||:.|:.|||..
Human   366 KYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQ 430

  Fly   545 GAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPP 609
            ||||||||||||...|.:|:.|||||:||:|..|:.|.|..|||.:...:|..::::||||..|.
Human   431 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQ 495

  Fly   610 GCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644
            |||..:::||..||:.|..:||||:.|...||..|
Human   496 GCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYF 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 27/54 (50%)
SH2_ABL 268..363 CDD:198189 39/103 (38%)
PTKc_Abl 382..644 CDD:270645 135/262 (52%)
FABD 1584..1723 CDD:197885
YES1NP_005424.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45
SH3_Yes 94..151 CDD:212940 28/57 (49%)
SH2_Src_family 154..253 CDD:199827 38/98 (39%)
PTKc_Yes 264..542 CDD:270654 137/270 (51%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.