DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and TXK

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens

Alignment Length:	477	Identity:	186/477 - (38%)
Similarity:	266/477 - (55%)	Gaps:	33/477 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SKENLLAPGP--EEDDPQLFV-ALYDFQAGGENQLSLKKGEQVRIL-SYNKSGEWCEAHSDSGNV 253
            ||...|.|.|  |..:.::.| |||||.......|:|::.|:..|| .||.  .|.:|....||.
Human    70 SKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNP--HWWKARDRLGNE 132

  Fly   254 GWVPSNYVT--PLNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISL----- 310
            |.:||||||  .:.:||.:.|||..|:||.||:|| .....|:|:||:|... |..:||:
Human   133 GLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGAR 196

  Fly   311 -RYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNK--PTV 372
             ..|..:.||:|.::..|:.:|.:...|.::.||:.:|.  |...||:|.|.||......  |..
Human   197 RSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQ--HNAAGLMTRLRYPVGLMGSCLPAT 259

  Fly   373 FPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIM 437
            ...|.|  :|||..:::....::|.||:|.|:...|:.: ..||:|.:.|.:|:.:||:|||.:|
Human   260 AGFSYE--KWEIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVM 321

  Fly   438 KEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLE 502
            .::.|..||||.|||.:..|.||:||||.:|.||::||. .:..|....||.:...|..||.|||
Human   322 MKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 385

  Fly   503 SRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKS 567
            ...|||||||||||||....:||::|||:.|.:.||.|.:..||||||||:.||...:||:|:||
Human   386 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 450

  Fly   568 DVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPT 632
            |||:||||:||:.|.|..|:.......|...:.:|:|:.||...|..:|::|..||......|||
Human   451 DVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPT 515

  Fly   633 FKSIHHALEHMFQESSITEAVE 654
            |..:..|         :||..|
Human   516 FAELLRA---------VTEIAE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	24/57 (42%)
		SH2_ABL	268..363	CDD:198189	34/101 (34%)
		PTKc_Abl	382..644	CDD:270645	113/261 (43%)
		Pkinase_Tyr	389..640	CDD:285015	109/250 (44%)
		FABD	1584..1723	CDD:197885
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	23/55 (42%)
		SH2_Tec_Txk	146..251	CDD:198261	37/107 (35%)
		PTKc_Tec_like	269..524	CDD:173637	111/265 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820